本文選題：單絨毛膜雙胎 + 選擇性宮內(nèi)生長(zhǎng)受限��； 參考：《現(xiàn)代婦產(chǎn)科進(jìn)展》2017年08期

【摘要】：目的:探討合并臍血流異常對(duì)選擇性宮內(nèi)生長(zhǎng)受限(s IUGR)臍血血漿代謝組學(xué)的影響。方法:納入6對(duì)合并臍血流異常及3對(duì)臍血流正常(對(duì)照組)的s IUGR雙胎,利用氣相色譜-飛行時(shí)間質(zhì)譜技術(shù)(GC-TOF/MS)對(duì)雙胎臍血進(jìn)行代謝物檢測(cè),通過(guò)主成分分析(PCA)和正交偏最小二乘判別分析(OPLS-DA)對(duì)質(zhì)譜數(shù)據(jù)進(jìn)行多元變量模式識(shí)別分析,根據(jù)模型的變量投影重要性、學(xué)生t檢驗(yàn)篩選可能的標(biāo)記物,并進(jìn)行代謝通路分析。結(jié)果:合并臍血流異常s IUGR篩選出17種有統(tǒng)計(jì)學(xué)意義的差異代謝物。其中谷氨酸、草酸、環(huán)亮氨酸、N-(2-羥乙基)亞氨基二乙酸及L-犬尿氨酸在s IUGR合并臍血流異常組增加,天冬氨酸、N-乙酰-L-天冬氨酸、乳酸、L-蘇糖、酪氨酸、甘氨酸、富馬酸、β-甘露糖基甘油酸、β-丙氨酸、亞油酸、棕櫚酸和馬來(lái)酰胺酸則降低。結(jié)論:GC-TOF/MS方法證實(shí)合并臍血流異常的s IUGR代謝組學(xué)發(fā)生改變,主要體現(xiàn)在脂質(zhì)、碳水化合物、氨基酸、能量、核酸、輔助因子和維生素代謝等方面。
[Abstract]:Objective: to investigate the effect of umbilical blood flow abnormality on plasma metabolism in selective intrauterine growth restriction (IUGR). Methods: six pairs of s IUGR twins with abnormal umbilical blood flow and 3 pairs of normal umbilical blood flow (control group) were included. The metabolites of umbilical cord blood were detected by gas chromatography-time of flight mass spectrometry (GC-TOF / MS). The multivariate pattern recognition analysis of mass spectrum data was carried out by means of principal component analysis (PCA) and orthogonal partial least squares discriminant analysis (OPLS-DA). According to the importance of variable projection of the model, the student t test was used to screen the possible markers and the metabolic pathway was analyzed. Results: 17 different metabolites with abnormal umbilical blood flow were screened by s IUGR. Glutamic acid, oxalic acid, cycloleucine N-ketoxyethyl) iminodiacetic acid and L-canine uric acid were increased in IUGR with abnormal umbilical blood flow, aspartic acid was N-acetyl-L-aspartic acid, L-threonose lactate, tyrosine, glycine, Fumaric acid, 尾 -mannose glyceric acid, 尾 -alanine, linoleic acid, palmitic acid and maleic acid decreased. Conclusion the changes of s IUGR metabolism in patients with abnormal umbilical blood flow were confirmed by the% GC-TOF / MS method, mainly in the metabolism of lipids, carbohydrates, amino acids, energy, nucleic acids, cofactors and vitamins.
【作者單位】： 北京大學(xué)第三醫(yī)院婦產(chǎn)科;
【基金】：“生殖健康及重大出生缺陷防控研究”重點(diǎn)專項(xiàng)(項(xiàng)目編號(hào)2016YFC1000400,課題編號(hào)2016YFC1000408)
【分類號(hào)】：R714.5

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