發(fā)布時(shí)間：2018-05-13 02:31

  本文選題：醫(yī)源性卵巢早衰 + 清髓化療��； 參考：《中國(guó)婦產(chǎn)科臨床雜志》2015年05期

【摘要】：目的了解女性血液病清髓性化療后卵巢早衰患者性激素治療(hormone therapy,HT)前后圍絕經(jīng)期癥狀的發(fā)生情況及自我認(rèn)知。方法 2011年12月至2013年12月,就診于北京大學(xué)人民醫(yī)院婦科門診的女性血液病清髓性化療造血干細(xì)胞移植術(shù)后符合診斷標(biāo)準(zhǔn)的卵巢早衰患者142例。問(wèn)卷形式調(diào)查其月經(jīng)情況、性激素水平、圍絕經(jīng)期癥狀并評(píng)估激素治療后圍絕經(jīng)期癥狀緩解特點(diǎn)。結(jié)果 1 142例患者中103例填寫了改良的Kupperman評(píng)分表,82例出現(xiàn)了圍絕經(jīng)期癥狀(79.6%),Kupperman絕經(jīng)指數(shù)評(píng)分(KMI)平均為13.50分,96例填寫了焦慮/抑郁(HAD)評(píng)分量表,6例出現(xiàn)焦慮,平均8.83分,4例出現(xiàn)抑郁,平均8.33分;2 105例接受了激素類藥物治療(94.6%),隨訪95例接受HT治療患者中71例有規(guī)律撤退性出血。51例訴月經(jīng)量明顯少于移植前月經(jīng)量,且經(jīng)血顏色變暗,差異有統(tǒng)計(jì)學(xué)意義(P=0.00,P0.05);3周期性激素治療后KMI總分平均為6.7,且下降有統(tǒng)計(jì)學(xué)意義。結(jié)論 1血液疾病清髓性化療劑量可導(dǎo)致卵巢功能提早衰竭;2性激素治療也可以緩解清髓化療后患者出現(xiàn)的圍絕經(jīng)期癥狀;3血液疾病清髓化療后卵巢早衰患者對(duì)圍絕經(jīng)期癥狀的認(rèn)知缺乏。
[Abstract]:Objective to investigate the occurrence of peri-menopausal symptoms before and after hormone therapy and self-cognition in women with premature ovarian failure after antimedullary chemotherapy. Methods from December 2011 to December 2013, 142 patients with ovarian premature failure who met the diagnostic criteria were enrolled in the department of gynecology of Peking University people's Hospital. Questionnaires were used to investigate menstrual status, sex hormone level, symptoms of perimenopausal period and to evaluate the characteristics of remission of menopausal symptoms after hormone therapy. Results among the 1 142 patients, 103 cases filled out the modified Kupperman scale and 82 cases developed peri-menopausal symptoms. The average score of Kupperman menopausal index was 13.50% and 96 cases filled out anxiety / depression scale. 6 cases developed anxiety. An average of 8.83 minutes was found in 4 patients with depression, and an average of 8.33 minutes and 2,105 patients received hormone drugs. Among the 95 patients receiving HT treatment, 71 cases had regular retreating bleeding. 51 cases reported menstrual volume was significantly less than that before transplantation, and the menstrual blood color became dark. The difference was statistically significant (P < 0.05). The average total score of KMI was 6.7, and the decrease was statistically significant. Conclusion (1) the dosage of antimedullary chemotherapeutic therapy in patients with hematologic diseases can lead to premature ovarian failure. It can also relieve the peri-menopausal symptoms of patients with hematological diseases. Lack of awareness of peri-menopausal symptoms.
【作者單位】： 北京大學(xué)人民醫(yī)院婦產(chǎn)科;河北醫(yī)科大學(xué)第二醫(yī)院婦產(chǎn)科;
【基金】：首都特色基金(Z121107001012031)
【分類號(hào)】：R711.75

【共引文獻(xiàn)】

相關(guān)期刊論文 前10條

1 姚斌;;絕經(jīng)期激素替代治療30例臨床分析[J];當(dāng)代醫(yī)學(xué);2013年34期

2 王彥潔;楊欣;趙e，

本文編號(hào)：1881270