本文選題：體外受精-胚胎移植 + 妊娠率��； 參考：《中國(guó)實(shí)用婦科與產(chǎn)科雜志》2015年04期

【摘要】：目的探討全胚冷凍后凍融胚胎移植(FET)周期第3天(D3)卵裂期胚胎,第5、6天雙囊胚及單囊胚移植的臨床效果分析。方法回顧性分析2010年1月至2012年12月在河南省人民醫(yī)院生殖醫(yī)學(xué)研究所行體外受精-胚胎移植(IVF-ET)的不孕患者,以全胚玻璃化冷凍FET周期的患者為研究對(duì)象,根據(jù)患者的意愿分為D3胚胎移植組(A組,n=456);雙囊胚移植組(B組,n=106);單囊胚移植組(C組,n=402)。比較3組之間基本資料、IVF治療的妊娠結(jié)局。結(jié)果與A組比較,B、C兩組患者平均冷凍胚胎數(shù)、平均移植胚胎數(shù)少,移植周期率低,而種植率高,差異有統(tǒng)計(jì)學(xué)意義(P0.05);C組平均移植胚胎數(shù)亦少于B組,而B(niǎo)組臨床妊娠率、最初周期妊娠率高于A、C兩組,C組多胎率低于A、B兩組,差異均有統(tǒng)計(jì)學(xué)意義(P0.05);C組早期流產(chǎn)率顯著性低于A組,差異有統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論對(duì)于全胚冷凍患者,當(dāng)D3可利用胚胎個(gè)數(shù)≥4時(shí),囊胚培養(yǎng)后玻璃化冷凍,擇期FET周期選擇性單囊胚移植是目前最佳的冷凍策略和最有益的臨床處理方案。
[Abstract]:Objective to investigate the clinical effects of cryopreservation and thawed embryo transfer (FET3) in cleavage stage, double blastocyst and single blastocyst on the 5th and 6th day of frozen-thawed embryo transfer cycle. Methods from January 2010 to December 2012, the infertile patients who underwent IVF-ETS in the Institute of Reproductive Medicine, people's Hospital of Henan Province, were retrospectively analyzed. The patients with vitrified FET cycle were studied. According to the wishes of the patients, they were divided into three groups: D3 embryo transfer group (A group), double blastocyst transfer group (B group) and single blastocyst transplantation group (group C). The pregnancy outcomes of IVF therapy were compared among the three groups. Results compared with group A, the average number of frozen embryos, the average number of embryos transferred, the rate of transfer cycle were low, and the implantation rate was high. The average number of embryos transferred in group C was significantly lower than that in group B, and the clinical pregnancy rate in group B was lower than that in group B. The early abortion rate of group C was significantly lower than that of group A (P 0.05) and the rate of early abortion in group C was significantly lower than that in group A (P 0.05). Conclusion for whole embryo freezing patients, vitrification after blastocyst culture and selective FET cycle selective single blastocyst transplantation are the best cryopreservation strategies and the most beneficial clinical treatment scheme when the number of embryos can be used for D 3 or more than 4.
【作者單位】： 河南省人民醫(yī)院生殖醫(yī)學(xué)研究所;鄭州大學(xué)人民醫(yī)院;
【分類(lèi)號(hào)】：R714.8

【共引文獻(xiàn)】

相關(guān)期刊論文 前10條

1 佘宏;胡艷秋;李曉聰;;融合期胚胎和囊胚移植的探討[J];國(guó)際婦產(chǎn)科學(xué)雜志;2013年06期

2 朱光麗;呂玉珍;宋文月;;凍融囊胚移植在卵巢高反應(yīng)患者中的應(yīng)用價(jià)值[J];中國(guó)婦產(chǎn)科臨床雜志;2014年02期

3 李娜;范俊梅;劉忠宇;尉春華;姚元慶;;胚胎植入前遺傳學(xué)診斷的新進(jìn)展[J];國(guó)際生殖健康/計(jì)劃生育雜志;2014年02期

4 孫正怡;甄t熑，

本文編號(hào)：1830168