本文選題：卵巢癌 + 調(diào)節(jié)性T細(xì)胞　； 參考：《免疫學(xué)雜志》2015年12期

【摘要】：目的探討手術(shù)前后卵巢癌患者外周血CD4+CD25+Foxp3+、CD8+CD28-及CD8+Foxp3+調(diào)節(jié)性T細(xì)胞的變化及其臨床意義。方法流式細(xì)胞術(shù)檢測31例卵巢癌患者術(shù)前及術(shù)后外周血CD4+CD25+Foxp3+、CD8+CD28-及CD8+Foxp3+調(diào)節(jié)性T細(xì)胞的表達(dá)水平,并與20例卵巢良性腫瘤及20例健康體檢者做比較研究。結(jié)果卵巢癌患者外周血CD4+CD25+Foxp3+、CD8+CD28-及CD8+Foxp3+調(diào)節(jié)性T細(xì)胞的表達(dá)水平顯著高于卵巢良性腫瘤及健康體檢者(P0.01),Ⅲ/Ⅳ期卵巢癌患者外周血調(diào)節(jié)性T細(xì)胞表達(dá)水平顯著高于Ⅰ/Ⅱ期患者(P0.05);卵巢癌患者外周血調(diào)節(jié)性T細(xì)胞的表達(dá)水平與病理類型無關(guān);手術(shù)后卵巢癌患者外周血調(diào)節(jié)性T細(xì)胞的比例顯著低于手術(shù)前(P0.05);Ⅰ/Ⅱ期卵巢癌患者手術(shù)后調(diào)節(jié)性T細(xì)胞的比例與健康體檢者相比無統(tǒng)計(jì)學(xué)差異,而Ⅲ/Ⅳ期病人術(shù)后調(diào)節(jié)性T細(xì)胞的比例仍顯著高于健康體檢者(P0.05)。結(jié)論 CD4+CD25+Foxp3+、CD8+CD28-及CD8+Foxp3+調(diào)節(jié)性T細(xì)胞與卵巢癌的病理進(jìn)程及腫瘤負(fù)荷相關(guān)。
[Abstract]:Objective to investigate the changes of CD28- and CD8 Foxp3 regulatory T cells in peripheral blood of patients with ovarian cancer before and after operation. Methods the expression of CD28- and CD8 Foxp3 regulatory T cells in peripheral blood of 31 patients with ovarian cancer were detected by flow cytometry before and after operation, and compared with 20 patients with benign ovarian tumor and 20 healthy controls. Results the expression of CD28- and CD8 Foxp3 regulatory T cells in peripheral blood of patients with ovarian cancer was significantly higher than that of patients with benign ovarian tumors and healthy controls (P 0.01). The expression of regulatory T cells in peripheral blood of patients with stage 鈪，

本文編號(hào)：1820343