本文選題：宮頸上皮內(nèi)瘤變 + HPV感染��； 參考：《重慶醫(yī)科大學(xué)》2017年碩士論文

【摘要】：目的:通過分析高危型HPV感染的宮頸上皮內(nèi)瘤變(CIN)患者的陰道微生態(tài)狀況及LEEP術(shù)后HPV持續(xù)陽(yáng)性與陰道微生態(tài)狀況的關(guān)系,為CIN患者治療中恢復(fù)陰道微生態(tài)提供依據(jù)。方法:回顧2014年1月至2016年12月在我院宮頸病變中心進(jìn)行LEEP術(shù)的CIN患者治療前后陰道微生態(tài)狀況及術(shù)后HPV感染情況。結(jié)果:1542例患者中具有完整隨訪資料者845例,其中81.5%(711/845)的患者陰道微生態(tài)異常,37.2%(314/845)的患者檢測(cè)出明確致病菌,以細(xì)菌性陰道病(BV)為主,明顯高于其它陰道炎(P0.05)。接受LEEP術(shù)后,233例患者HPV持續(xù)陽(yáng)性,其中80.7%(188/233)患者陰道微生態(tài)異常,BV和VVC的感染率分別為37.3%(87/233)和6.9%(16/233);612例患者HPV轉(zhuǎn)陰,其中14.4%(88/612)患者微生態(tài)異常,BV及VVC的感染率分別為6%(37/612)和1.3%(8/612),與術(shù)后HPV持續(xù)陽(yáng)性患者相比,其陰道微生態(tài)異常率及BV、VVC的感染率明顯下降(P0.05)。結(jié)論:合并高危型HPV感染的CIN患者陰道微生態(tài)異常較為普遍,其中以BV感染最為常見,CIN患者LEEP術(shù)后HPV持續(xù)陽(yáng)性與陰道微生態(tài)異常相關(guān),尤其是BV、VVC感染引起的陰道炎有關(guān),提示清除致病菌、治療陰道炎、恢復(fù)陰道微生態(tài)在CIN治療及促使HPV轉(zhuǎn)陰中十分重要。
[Abstract]:Objective: to analyze the relationship between vaginal microecology and vaginal microecology in patients with high risk HPV infection of cervical intraepithelial neoplasia (cin), and to provide evidence for the recovery of vaginal microecology during the treatment of CIN patients. Methods: from January 2014 to December 2016, the vaginal microecology and postoperative HPV infection of CIN patients undergoing LEEP in our cervical lesion center were reviewed. Results there were 845 cases with complete follow-up data in 1 542 cases, among which 81.5% (711% 845) patients with abnormal vaginal microecology (37.214% 845) were found to have definite pathogenic bacteria, mainly bacterial vaginosis (BV), which was significantly higher than that of other vaginitis (P 0.05). The positive rates of HPV and VVC were 37.387 / 233and 6.910 / 233respectively in 80.7% / 188 / 233 (80.7% / 233) patients after LEEP, respectively. HPV turned negative in 612 cases. The infection rates of BV and VVC in patients with microecological abnormality were 637 / 612) and 1.38 / 612g respectively. Compared with the patients with persistent positive HPV after operation, the rate of abnormal vaginal microecology and the infection rate of VVC decreased significantly (P 0.05). Conclusion: vaginal microecological abnormalities are common in CIN patients with high risk HPV infection. Among them, the persistent positive HPV after LEEP in patients with BV infection is associated with vaginal microecological abnormalities, especially vaginitis caused by LEEP infection. It was suggested that eliminating pathogenic bacteria, treating vaginitis and restoring vaginal microecology were very important in the treatment of CIN and promoting HPV to turn negative.
【學(xué)位授予單位】：重慶醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類號(hào)】：R737.33

【參考文獻(xiàn)】

相關(guān)期刊論文 前10條

1 王寶晨;夏玉潔;王辰;范愛萍;王穎梅;張麗琴;薛鳳霞;;高危型人乳頭瘤病毒感染子宮頸上皮內(nèi)瘤變患者陰道微生態(tài)分析[J];中國(guó)婦產(chǎn)科臨床雜志;2016年06期

2 王美藏;高建宏;楊雅琴;;乳酸桿菌半定量、陰道清潔度及陰道炎癥與HPV感染的關(guān)系[J];中國(guó)婦幼保健;2016年22期

3 陳國(guó)斌;王穎;劉植華;;陰道乳酸桿菌與宮頸HPV感染及子宮頸癌前病變的相關(guān)性研究[J];中國(guó)現(xiàn)代藥物應(yīng)用;2016年12期

4 李東燕;郝敏;;陰道微生態(tài)平衡與高危型HPV感染分析[J];中國(guó)微生態(tài)學(xué)雜志;2016年05期

5 潘穎;盛華芳;康玲;馬嘯;鄭慧敏;周宏偉;劉木彪;;高危型人乳頭狀瘤病毒感染與陰道菌群的相關(guān)性研究[J];第三軍醫(yī)大學(xué)學(xué)報(bào);2016年13期

6 謝蘭;常淑芳;孫江川;張瀟元;秦勤;丁欽容;張永紅;;435例外陰上皮內(nèi)非瘤樣病變患者陰道微生態(tài)狀況分析[J];解放軍醫(yī)學(xué)雜志;2016年02期

7 曾育英;鐘繼生;;HPV感染者陰道細(xì)菌感染特征分析[J];中國(guó)醫(yī)學(xué)工程;2015年07期

8 蔣燕明;楊嵐;李立;;細(xì)菌性陰道病與宮頸上皮內(nèi)瘤變、高危型乳頭瘤病毒的關(guān)系研究[J];廣西醫(yī)科大學(xué)學(xué)報(bào);2014年05期

9 任忠良;何啟田;李凱旋;郭瑞林;;婦科就診人群高危HPV感染發(fā)生率與細(xì)菌性陰道病相關(guān)性調(diào)查[J];中國(guó)地方病防治雜志;2014年S2期

10 崔麗陽(yáng);岳天孚;;HR-HPV感染與其他女性生殖道感染因素的關(guān)系研究[J];中國(guó)婦幼保健;2014年03期

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