本文選題：高血壓 + 妊娠性��； 參考：《中國循環(huán)雜志》2017年09期

【摘要】：目的:探討可溶性晚期糖基化終末產(chǎn)物受體(s RAGE)在妊娠期高血壓性心臟病中的表達和臨床意義。方法:選擇2013-06至2016-07我院收治的57例符合妊娠期高血壓性心臟病診斷標準的患者作為觀察組,并收集同期正常妊娠患者57例作為對照組;將觀察組患者根據(jù)紐約心臟協(xié)會(NHYA)心功能Ⅰ~Ⅳ級又分為四個亞組,根據(jù)28 d生存與否分為存活組(n=49)和死亡組(n=8)兩個亞組。采用酶聯(lián)免疫吸附法(ELISA)檢測患者入院24 h內(nèi)血漿s RAGE,同時進行B型利鈉肽(BNP)水平測定。比較各組間患者s RAGE水平變化差異及分析s RAGE對妊娠期高血壓性心臟病患者預后的判斷價值。結(jié)果:觀察組患者血漿s RAGE濃度顯著高于對照組[(939.2±184.3)pg/ml vs(467.3±116.2)pg/ml,P0.05];觀察組患者血漿s RAGE水平與NYHA心功能分級呈正相關關系(r=0.76,P0.001),隨著心功能分級增加,血漿s RAGE濃度亦呈升高趨勢(P0.05);觀察組患者中死亡組的血漿s RAGE濃度明顯高于生存組[(1647.6±249.7)pg/ml vs(776.9±146.2)pg/ml,P0.05];s RAGE和BNP診斷妊娠期高血壓性心臟病的受試者操作特征曲線下面積分別為0.91和0.88,差異有統(tǒng)計學意義(P0.05)。結(jié)論:妊娠期高血壓性心臟病患者血漿s RAGE水平升高,血漿s RAGE水平與心力衰竭嚴重程度相關,可作為患者預后的早期預測指標。
[Abstract]:Objective: To investigate the expression and clinical significance of soluble advanced glycosylation end product receptor (s RAGE) in hypertensive heart disease of pregnancy. Methods: 57 patients with pregnancy induced hypertensive heart disease were selected from 2013-06 to 2016-07 as an observation group, and 57 cases of normal pregnancy were collected as control. The patients in the observation group were divided into four subgroups according to the heart function of the New York Heart Association (NHYA) heart function class I ~ IV. According to the survival of 28 d, the survival group (n=49) and the death group (n=8) were divided into two subgroups. The plasma s RAGE was detected by enzyme linked immunosorbent assay (ELISA), and the B type natriuretic peptide (BNP) was measured in the patients' admission to the hospital, and the level of B type natriuretic peptide (BNP) was measured. The difference of s RAGE level and the evaluation value of s RAGE on the prognosis of hypertensive heart disease in pregnancy. Results: the plasma s RAGE concentration in the observation group was significantly higher than that of the control group [(939.2 + 184.3) pg/ml vs (467.3 + 116.2) pg/ml, P0.05], and the plasma s RAGE level in the observation group was positively correlated with the classification of cardiac function. 01), with the increase of cardiac function, the plasma s RAGE concentration also increased (P0.05), and the plasma s RAGE concentration in the death group was significantly higher than that in the survival group [(1647.6 + 249.7) pg/ml vs (776.9 + 146.2) pg/ml, P0.05]; s RAGE and BNP diagnosed high blood pressure heart disease under the operating characteristic curve of the subjects were 0.91, respectively. 0.88, the difference was statistically significant (P0.05). Conclusion: the level of plasma s RAGE in patients with hypertensive heart disease of pregnancy was elevated, and the level of s RAGE in plasma was associated with the severity of heart failure, which could be used as an early predictor of prognosis.

【作者單位】： 甘肅省婦幼保健院急診科;
【分類號】：R714.252

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