本文選題：子宮頸腫瘤 + 鱗狀細(xì)胞癌　； 參考：《臨床與實(shí)驗(yàn)病理學(xué)雜志》2015年09期

【摘要】：目的探討半乳凝素-7(Galectin-7)在維吾爾族與漢族婦女子宮頸鱗狀細(xì)胞癌和子宮頸炎中的表達(dá),并分析其與HPV 16感染、子宮頸癌分化程度、患病年齡的相關(guān)性。方法采用免疫組化SP法分別檢測(cè)Galectin-7在維吾爾族21例子宮頸炎和49例子宮頸鱗狀細(xì)胞癌、漢族25例子宮頸炎和29例子宮頸鱗狀細(xì)胞癌中的表達(dá);采用PCR技術(shù)檢測(cè)HPV 16感染情況。利用圖像分析軟件Image-Pro Plus(IPP)6.0半定量檢測(cè)子宮頸病變中Galectin-7的累計(jì)光密度(integrated optical density,IOD)值。結(jié)果 PCR檢測(cè)顯示維吾爾族子宮頸鱗狀細(xì)胞癌中HPV 16陽(yáng)性者20例,陰性者29例;子宮頸炎中HPV 16陽(yáng)性者5例,陰性者16例。漢族子宮頸癌中HPV 16陽(yáng)性者2例,陰性者27例;子宮頸炎中HPV 16均陰性。Galectin-7在維吾爾族子宮頸鱗狀細(xì)胞癌中的表達(dá)低于子宮頸炎組織(P0.05),其在維吾爾族HPV 16陽(yáng)性子宮頸鱗狀細(xì)胞癌組織中的表達(dá)低于HPV 16陰性組織(P0.05)。Galectin-7表達(dá)與子宮頸鱗狀細(xì)胞癌分化程度、患病年齡無(wú)相關(guān)性(P0.05)。結(jié)論維吾爾族子宮頸鱗狀細(xì)胞癌與子宮頸炎組織相比,Galectin-7表達(dá)量下降;另外其在維吾爾族HPV 16陽(yáng)性子宮頸鱗狀細(xì)胞癌中的表達(dá)低于HPV 16陰性者,這可能與子宮頸鱗狀細(xì)胞癌的發(fā)生、發(fā)展、浸潤(rùn)、轉(zhuǎn)移密切相關(guān),檢測(cè)其表達(dá)對(duì)維吾爾族婦女子宮頸癌診斷有一定的參考價(jià)值。
[Abstract]:Objective to investigate the expression of galectin-7 in cervical squamous cell carcinoma and cervicitis in Uygur and Han women, and to analyze the correlation between galectin-7 and HPV 16 infection, cervical cancer differentiation and age. Methods Immunohistochemical SP method was used to detect the expression of Galectin-7 in 21 cases of cervicitis in Uygur nationality, 49 cases of squamous cell carcinoma of cervix, 25 cases of cervicitis and 29 cases of cervical squamous cell carcinoma in Han nationality, and the infection of HPV 16 was detected by PCR technique. The accumulative optical density (Galectin-7) and integrated optical density (IOD) of Galectin-7 in cervical lesions were detected by image analysis software Image-Pro Plus(IPP)6.0. Results PCR showed that HPV 16 was positive in 20 cases and negative in 29 cases in Uygur cervix squamous cell carcinoma, and HPV 16 was positive in 5 cases and negative in 16 cases in cervicitis. HPV 16 was positive in 2 cases and negative in 27 cases of cervical cancer in Han nationality. The expression of HPV 16 negative. Galectin-7 in Uygur cervical squamous cell carcinoma was lower than that in Uygur cervicitis tissue P0.05, and its expression in Uygur HPV 16 positive cervical squamous cell carcinoma was lower than that in HPV 16 negative tissue. Galectin-7 Expression and differentiation of cervical squamous cell carcinoma, There was no correlation between the age of disease and the age of disease (P 0.05). Conclusion the expression of Galectin-7 in Uygur cervical squamous cell carcinoma is lower than that in cervicitis, and the expression of Galectin-7 in Uygur cervical squamous cell carcinoma is lower than that of HPV 16 negative. This may be closely related to the occurrence, development, invasion and metastasis of cervical squamous cell carcinoma. The detection of its expression may be useful for the diagnosis of cervical cancer in Uygur women.
【作者單位】： 新疆醫(yī)科大學(xué)臨床醫(yī)學(xué)院;新疆醫(yī)科大學(xué)組胚教研室;
【基金】：國(guó)家級(jí)大學(xué)生創(chuàng)新項(xiàng)目(CX2013012)
【分類號(hào)】：R737.33

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