本文選題：益腎寧坤方 + 中藥��； 參考：《南京中醫(yī)藥大學(xué)》2014年碩士論文

【摘要】：目的：觀察益腎寧坤方對(duì)子宮內(nèi)膜異位癥術(shù)后加用GnRH-a所致肝腎陰虛型圍絕經(jīng)期癥狀的療效并探討其機(jī)理。方法：所有患者為腹腔鏡下卵巢巧克力囊腫剝除術(shù),術(shù)后加用醋酸亮丙瑞林藥物治療,共6針24周,使用12周后出現(xiàn)符合肝腎陰虛型圍絕經(jīng)期癥狀的病例共90例,按隨機(jī)數(shù)字表法分成三組治療12周,其中對(duì)照組30例,單用醋酸亮丙瑞林,反向添加組30例同時(shí)每日加用替勃龍片(1.25mg/d)反向添加,口服中藥組30例同時(shí)每日口服中藥益腎寧坤方。治療后比較三組患者潮熱出汗、失眠、易激動(dòng)、疲乏、骨關(guān)節(jié)肌肉痛、性生活障礙各項(xiàng)癥狀的改良Kupperman評(píng)分,并檢測(cè)血清雌二醇(estradiol, E2)、卵泡刺激素(follicle-stimulating hormone, FSH)水平。觀察三組患者盆腔超聲及血清CA125情況。結(jié)果：各項(xiàng)癥狀的評(píng)分比較,對(duì)照組和反向添加組、對(duì)照組和口服中藥組,差異均有統(tǒng)計(jì)學(xué)意義(P0.05),反向添加組和口服中藥組,差異均無(wú)統(tǒng)計(jì)學(xué)意義(P0.05)。血清E2、FSH水平的比較,對(duì)照組和反向添加組、對(duì)照組和口服中藥組在統(tǒng)計(jì)學(xué)上有顯著性差異(P0.05),反向添加組和口服中藥組無(wú)顯著性差異(P0.05)。三組復(fù)查均無(wú)復(fù)發(fā)病例。結(jié)論：內(nèi)異癥術(shù)后加用促性腺激素釋放激素類(lèi)似物(gonadotrophin-releasing hormone agonist, GnRH-a)時(shí),口服中藥益腎寧坤方,不僅不影響內(nèi)異癥的療效,而且可以明顯減輕GnRH-a所致的圍絕經(jīng)期癥狀。
[Abstract]:Objective: to observe the effect of Yishen Ningkun recipe on the peri-menopausal symptoms of liver-kidney yin deficiency syndrome induced by GnRH-a and its mechanism. Methods: all the patients were treated by laparoscopic excision of chocolate cyst of ovary and treated with Leuprorelin Acetate for 24 weeks. After 12 weeks of treatment, 90 cases were found to be in line with the peri-menopausal symptoms of liver-kidney yin deficiency type. Three groups were randomly divided into three groups: control group (n = 30), control group (n = 30), control group (n = 30), control group (n = 30), reverse admixture group (n = 30) and tibolone group (n = 30), respectively. 30 patients in the oral Chinese medicine group were treated with Yishen Ningkun prescription daily at the same time. After treatment, the modified Kupperman scores of the symptoms of hot tidal sweating, insomnia, agitation, fatigue, osteoarticular muscle pain and sexual disturbance were compared, and serum estradiol, E _ 2 and follicle-stimulating hormone follicle-stimulating hormone (FSHs) were measured. Pelvic ultrasound and serum CA125 were observed in three groups. Results: there were significant differences in the scores of each symptom between the control group and the reverse addition group, the control group and the oral Chinese medicine group, but there was no significant difference between the reverse addition group and the oral Chinese medicine group (P 0.05). The comparison of serum E2FSH levels showed that there were significant statistical differences between the control group and the reverse adding group, the control group and the oral Chinese medicine group (P 0.05), but there was no significant difference between the reverse addition group and the oral Chinese medicine group (P 0.05). There were no recurrence cases in all three groups. Conclusion: when the gonadotrophin-releasing hormone antagonist (GnRH-a) is added to the patients with endometriosis after operation, the oral administration of Yishen Ningkun prescription not only does not affect the curative effect of endometriosis, but also can obviously alleviate the peri-menopausal symptoms caused by GnRH-a.
【學(xué)位授予單位】：南京中醫(yī)藥大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2014
【分類(lèi)號(hào)】：R713.4

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本文編號(hào)：1776859