發(fā)布時間：2018-04-18 01:35

  本文選題：凍融胚胎移植 + 垂體降調(diào)節(jié)�。� 參考：《現(xiàn)代婦產(chǎn)科進展》2015年06期

【摘要】：目的:比較3.75mg GnRHa降調(diào)節(jié)激素替代內(nèi)膜準(zhǔn)備方案與單純激素替代內(nèi)膜準(zhǔn)備方案對凍融胚胎移植(FET)妊娠率的影響。方法:選取1225例(周期)行凍融胚胎移植患者,根據(jù)內(nèi)膜準(zhǔn)備方式分為激素替代周期組(A組)417例和降調(diào)節(jié)激素替代組808(B組)例。比較兩組患者的種植率、妊娠率、流產(chǎn)率和生殖激素水平。結(jié)果:激素替代周期組和降調(diào)節(jié)激素替代組患者的種植率分別為33.6%和38.1%,臨床妊娠率分別為52.3%和58.8%;兩組的種植率和臨床妊娠率比較差異均有統(tǒng)計學(xué)意義(P0.05)。降調(diào)節(jié)激素替代組的黃體酮注射日、ET前1日和ET后第3日LH低于A組,差異有統(tǒng)計學(xué)意義(P0.05)。兩組患者的流產(chǎn)率和異位妊娠率比較,差異無統(tǒng)計學(xué)意義(P0.05)。結(jié)論:與傳統(tǒng)激素替代內(nèi)膜準(zhǔn)備方案比較,3.75mg GnRHa降調(diào)節(jié)激素替代內(nèi)膜準(zhǔn)備方式可提高凍融胚胎移植妊娠率而不增加流產(chǎn)率。
[Abstract]:Aim: to compare the effects of 3.75mg GnRHa down-regulation hormone replacement endometrium preparation regimen and hormone replacement endometrium preparation regimen on pregnancy rate of frozen and thawed embryo transfer.Methods: 1225 cases of frozen and thawed embryo transfer were selected and divided into two groups according to the preparation of endometrium: group A (n = 417) and group B (n = 808).The implantation rate, pregnancy rate, abortion rate and reproductive hormone level were compared between the two groups.Results: the implantation rate was 33.6% and 38.1%, and the clinical pregnancy rate was 52.3% and 58.8% in the hormone replacement cycle group and the descending regulation hormone replacement group, respectively, and there was significant difference between the two groups in the implantation rate and the clinical pregnancy rate.The LH of the hyporegulation hormone replacement group was lower than that of group A on the day of progesterone injection and on the 3rd day after et, and the difference was statistically significant (P 0.05).There was no significant difference in abortion rate and ectopic pregnancy rate between the two groups (P 0.05).Conclusion: compared with the traditional hormone replacement endometrial preparation regimen, 3.75mg GnRHa down-regulation hormone replacement endometrial preparation can improve the pregnancy rate of frozen-thawed embryo transfer, but not the abortion rate.
【作者單位】： 湖北醫(yī)藥學(xué)院附屬人民醫(yī)院生殖醫(yī)學(xué)中心;
【分類號】：R714.8

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本文編號：1766231