本文選題：紫杉醇脂質體 + 紫杉醇注射液��； 參考：《中國藥物警戒》2016年12期

【摘要】：目的比較紫杉醇脂質體或紫杉醇注射液聯(lián)合順鉑治療中晚期宮頸癌的臨床效果與安全性差異。方法選取2009年6月~2010年6月在我院診治的中晚期宮頸癌患者83例,隨機分為觀察組42例和對照組41例,觀察組第1天給予紫杉醇脂質體135 mg·m-2靜脈滴注,第2天給予順鉑60 mg·m-2靜脈滴注;對照組第1天給予紫杉醇注射液135 mg·m-2靜脈滴注,第2天給予順鉑60 mg·m-2靜脈滴注。兩組患者皆采取同步放化療方案,比較兩組患者治療宮頸癌的臨床效果(近期療效和遠期療效)及安全性差異。結果觀察組治療宮頸癌的有效緩解率為83.33%,對照組為68.29%,差異有統(tǒng)計學意義(P0.05);觀察組的宮頸癌旁浸潤和淋巴結轉移顯著低于對照組,5年生存率顯著高于對照組(P0.05);觀察組在脫發(fā)、胃腸道反應、過敏反應、骨髓抑制及免疫力下降等不良反應方面與對照組相比存在顯著安全性差異(P0.05)。結論紫杉醇脂質體聯(lián)合順鉑治療宮頸癌的近期療效和遠期療效良好,且安全性相對較高。
[Abstract]:Objective to compare the efficacy and safety of paclitaxel liposome or paclitaxel injection combined with cisplatin in the treatment of advanced cervical cancer.Methods Eighty-three patients with advanced cervical cancer treated in our hospital from June 2009 to June 2010 were randomly divided into observation group (n = 42) and control group (n = 41).On the second day, cisplatin 60 mg m-2 was given intravenously, while in the control group, paclitaxel injection 135 mg m-2 and cisplatin 60 mg m-2 were given intravenously on day 1 and day 2, respectively.Patients in both groups were treated with concurrent radiotherapy and chemotherapy. The clinical efficacy (short-term and long-term efficacy) and safety were compared between the two groups in the treatment of cervical cancer.Results the effective remission rate of cervical cancer in the observation group was 83.33 and that in the control group was 68.29, the difference was statistically significant (P 0.05), the adjacent invasion and lymph node metastasis in the observation group were significantly lower than those in the control group, and the 5-year survival rate was significantly higher than that in the control group (P 0.05).Compared with the control group, the safety of gastrointestinal reaction, allergic reaction, bone marrow suppression and immunosuppression were significantly different (P 0.05).Conclusion the efficacy of paclitaxel liposome combined with cisplatin in the treatment of cervical cancer is good and the safety is relatively high.
【作者單位】： 南京醫(yī)科大學附屬淮安第一醫(yī)院;
【分類號】：R737.33

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