本文選題：盆腔器官脫垂 + 基因多態(tài)性��； 參考：《河南科技大學(xué)》2017年碩士論文

【摘要】：背景和目的:近年來(lái),盆腔器官脫垂的發(fā)病率有所升高,嚴(yán)重影響著患者的工作和生活,且生活質(zhì)量明顯下降。盆腔器官脫垂的病因不明,眾多學(xué)者認(rèn)為和分娩、家族、肥胖等有關(guān)�；蚨鄳B(tài)性的研究為疾病的發(fā)生發(fā)展揭開(kāi)了神秘的面紗。近年來(lái)有不少學(xué)者研究盆腔器官脫垂與COL3A1基因多態(tài)性之間的相關(guān)性,但是他們的研究結(jié)論存在分歧。本文旨在通過(guò)Meta分析探討COL3A1的基因多態(tài)性與盆腔器官脫垂的發(fā)病易感性是否具有相關(guān)性,以及進(jìn)一步探討該基因的多態(tài)性是否增加盆腔器官脫垂的發(fā)病風(fēng)險(xiǎn),以期為盆腔器官脫垂的病因?qū)W提供一定的循證醫(yī)學(xué)證據(jù)。方法:通過(guò)對(duì)Pubmed、Medline、Embase、Cochrane、CNKI、萬(wàn)方數(shù)據(jù)庫(kù)檢索從建庫(kù)至2016年10月的相關(guān)文獻(xiàn),提取數(shù)據(jù),利用Review Manager 5.2軟件對(duì)合并后的數(shù)據(jù)進(jìn)行Meta分析,從而探討COL3A1基因多態(tài)性和盆腔器官脫垂發(fā)生易感性的相關(guān)性。結(jié)果:研究共納入5篇文章,其中包括1274名參與者(701名病例和573名對(duì)照)。等位基因A vs G:OR=0.98,95%CI 0.67-1.43,P=0.92;純合子模型AA vs GG:OR=1.51,95%CI 0.47-4.82,P=0.48;雜合子模型GA vs GG:OR=0.89,95%CI 0.69-0.14,P=0.37;顯性模型GA+AA vs GG:OR=0.92,95%CI 0.63-1.33,P=0.65;隱性模型AA vs GA+AA:OR=1.64,95%CI 0.54-4.95,P=0.38。結(jié)論:通過(guò)分析本研究的數(shù)據(jù)所得的森林圖可知,COL3A1基因的多態(tài)性與盆腔器官脫垂的發(fā)病易感性無(wú)明顯相關(guān)性,但是由亞組分析可知,盆腔器官脫垂的發(fā)生可能和種族有關(guān)。
[Abstract]:Background and objective: in recent years, the incidence of pelvic organ prolapse has increased, which seriously affected the work and life of patients, and the quality of life decreased significantly.The etiology of pelvic organ prolapse is unknown, and many scholars believe that it is related to childbirth, family, obesity and so on.The study of genetic polymorphisms has revealed the mystery of the occurrence and development of disease.In recent years, many researchers have studied the association between pelvic organ prolapse and COL3A1 gene polymorphism, but their conclusions are different.The aim of this study was to investigate the association between COL3A1 gene polymorphism and the susceptibility to pelvic organ prolapse by Meta analysis, and to further explore whether the polymorphism of the gene increased the risk of pelvic organ prolapse.In order to provide evidence-based medical evidence for the etiology of pelvic organ prolapse.Methods: through the retrieval of relevant documents from the establishment of the database to October 2016, the Review Manager 5.2 software was used to analyze the combined data by using Review Manager 5.2 software.To investigate the association between COL3A1 gene polymorphism and susceptibility to pelvic organ prolapse.Results: the study included 5 articles, including 1274 participants with 701 cases and 573 controls.Allele A vs GGO: 0.9895 CI 0.67-1.43P0.92; homozygous AA vs GGOR1.5195 95 CI 0.47-4.82 P0.48; heterozygote model GA vs GG: OR0.8995 CI 0.69-0.14P0.37; dominant model GA vs GGOR0.995 CI 0.63-1.33P0.65; recessive model AA vs GA > 1.6495CI 0.54-4.95P0. 38.Conclusion: there is no significant correlation between the polymorphism of COL3A1 gene and the susceptibility of pelvic organ prolapse, but the subgroup analysis shows that the occurrence of pelvic organ prolapse may be related to race.
【學(xué)位授予單位】：河南科技大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類號(hào)】：R711.2

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