本文選題：卵巢交界性腫瘤 + 保守�。� 參考：《蘭州大學(xué)》2017年碩士論文

【摘要】：目的:系統(tǒng)評(píng)價(jià)卵巢交界性腫瘤(Borderline Ovarian Tumors,BOTs)保守手術(shù)術(shù)后復(fù)發(fā)的危險(xiǎn)因素,為臨床治療和隨訪提供依據(jù)。方法:計(jì)算機(jī)檢索PubMed、EMbase、The Cochrane Library(2016年第12期)、Web of Science、CNKI、CBM、WanFang Data、VIP等數(shù)據(jù)庫(kù),搜集所有研究卵巢交界性腫瘤保守手術(shù)術(shù)后復(fù)發(fā)危險(xiǎn)因素的隊(duì)列研究或病例對(duì)照研究,檢索時(shí)限均從建庫(kù)至2016年12月31日,同時(shí)手工檢索相關(guān)國(guó)內(nèi)期刊雜志,由2位研究員按照納入、排除標(biāo)準(zhǔn)獨(dú)立篩選文獻(xiàn)、提取資料并評(píng)價(jià)納入研究的偏倚風(fēng)險(xiǎn)后,采用RevMan5.3軟件進(jìn)行Meta分析。結(jié)果:全文最終納入20個(gè)隊(duì)列研究,共1064例患者。Meta分析結(jié)果顯示:在術(shù)后復(fù)發(fā)率方面,FIGO≥Ⅱ期和FIGOⅠ期[OR=3.32,95%CI(1.56,7.05),P=0.002]、雙側(cè)卵巢腫瘤和單側(cè)卵巢腫瘤[OR=3.51,95%CI(1.73,7.10),P=0.0005]、卵巢囊腫切除術(shù)和單側(cè)附件切除術(shù)[OR=2.88,95%CI(1.82,4.56),P0.00001]、腫瘤包膜破裂和腫瘤包膜未破裂[OR=8.93,95%CI(2.73,29.20),P=0.0003]、交界性漿液性卵巢腫瘤(Serous Borderline Ovarian Tumors,SBOT)和交界性黏液性卵巢腫瘤(Mucinous Borderline Ovarian Tumors,MBOT)[OR=2.21,95%CI(1.49,3.28),P0.0001]、微乳頭浸潤(rùn)和無(wú)微乳頭浸潤(rùn)[OR=2.36,95%CI(1.32,4.24),P=0.004]的術(shù)后復(fù)發(fā)率差異有統(tǒng)計(jì)學(xué)意義,而FIGOⅠC期和FIGO≤ⅠB期[OR=1.32,95%CI(0.74,2.33),P=0.34]、術(shù)前CA125升高和術(shù)前CA125正常[OR=1.37,95%CI(0.53,3.53),P=0.51]、腹腔鏡手術(shù)和開(kāi)腹手術(shù)[OR=1.27,95%CI(0.88,1.85),P=0.20]、分期手術(shù)和未分期手術(shù)[OR=0.38,95%CI(0.11,1.26),P=0.11]、清掃淋巴結(jié)和未清掃淋巴結(jié)[OR=1.21,95%CI(0.34,4.30),P=0.77]、微浸潤(rùn)和無(wú)微浸潤(rùn)[OR=1.25,95%CI(0.69,2.25),P=0.46]、術(shù)后化療和術(shù)后未化療[OR=1.12,95%CI(0.43,2.90),P=0.81]對(duì)術(shù)后復(fù)發(fā)率的影響無(wú)統(tǒng)計(jì)學(xué)差異。結(jié)論:FIGO≥Ⅱ期、雙側(cè)卵巢腫瘤、卵巢囊腫切除術(shù)、腫瘤包膜破裂、SBOT、微乳頭浸潤(rùn)是卵巢交界性腫瘤保守手術(shù)術(shù)后復(fù)發(fā)的危險(xiǎn)因素。
[Abstract]:Objective: to evaluate the risk factors for recurrence of borderline Ovarian tumors after conservative surgery, and to provide evidence for clinical treatment and follow-up.Methods: a computer-based search of the Cochrane Library (issue 12 of 2016) was conducted to collect all cohort studies or case-control studies on the risk factors of recurrence of ovarian borderline tumors after conservative surgery.The time limit for retrieval was from the establishment of the database to December 31, 2016, and the relevant domestic periodical magazines were manually searched, which were included by two researchers, excluding the criteria for independent screening of literature, extracting data and evaluating the bias risks involved in the study.Meta analysis was carried out with RevMan5.3 software.Results: the full text was included in 20 cohort studies.鑰孎IGO鈪燙鏈熷拰FIGO鈮も厾B鏈焄OR=1.32,95%CI(0.74,2.33),P=0.34],鏈墠CA125鍗囬珮鍜屾湳鍓岰A125姝ｅ父[OR=1.37,95%CI(0.53,3.53),P=0.51],鑵硅厰闀滄墜鏈拰寮，

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