本文選題：宮頸癌 + 骨橋蛋白　； 參考：《中國老年學(xué)雜志》2017年18期

【摘要】：目的探討宮頸癌患者血清骨橋蛋白(OPN)、可溶性E-鈣黏蛋白(sE-cadherin)含量與腫瘤增殖、侵襲活性的相關(guān)性。方法宮頸癌患者70例為宮頸癌組,宮頸不典型增生患者58例為不典型增生組,宮頸炎癥患者60例作為炎癥組。入院后當(dāng)天,采用二抗間接法測定血清OPN含量,采用酶聯(lián)免疫吸附法(ELISA)測定sE-cadherin含量;采用RT-PCR法測定宮頸組織增殖基因、侵襲基因mRNA表達(dá)量。結(jié)果宮頸癌組血清OPN含量高于不典型增生組、炎癥組,sE-cadherin含量低于不典型增生組、炎癥組(P0.05);宮頸癌組的組織增殖基因GBP1、caveolin-1 mRNA表達(dá)量低于不典型增生組、炎癥組,Bcl-xL、Sp2、EZH2 mRNA表達(dá)量高于不典型增生組、炎癥組(P0.05);宮頸癌組的組織侵襲基因Prdx4、Sox2、Rab11、RbAp48 mRNA表達(dá)量高于不典型增生組、炎癥組(P0.05)。宮頸癌血清OPN、sE-cadherin含量與以上腫瘤增殖、侵襲活性基因均有一定的相關(guān)性(P0.05)。結(jié)論宮頸癌患者血清中OPN高表達(dá)、sE-cadherin低表達(dá),其含量與腫瘤增殖、侵襲程度存在直接相關(guān)性。
[Abstract]:Objective to investigate the correlation between serum osteopontin (OPN), soluble E-cadherin (E-cadherin) and tumor proliferation and invasion activity in patients with cervical cancer.Methods 70 patients with cervical cancer, 58 patients with atypical hyperplasia of cervix and 60 patients with cervix inflammation were treated as inflammation group.On the day of admission, the content of serum OPN was determined by the second antibody indirect method, the content of sE-cadherin was determined by Elisa, and the expression of proliferative gene and invasive gene mRNA in cervical tissue was determined by RT-PCR method.Results the level of serum OPN in cervical cancer group was higher than that in atypical hyperplasia group, the content of sE-cadherin in inflammatory group was lower than that in atypical hyperplasia group, and the expression of tissue proliferative gene GBP1caveolin-1 mRNA in cervical cancer group was lower than that in atypical hyperplasia group.The expression of EZH2 mRNA in inflammatory group was higher than that in atypical hyperplasia group (P 0.05), and the expression of invasive gene Prdx4, Sox2, Rab11RbAp48 mRNA in cervical carcinoma group was higher than that in atypical hyperplasia group, and the expression level of P0.05 in inflammatory group was higher than that in atypical hyperplasia group.The level of serum OPNNs E-cadherin in cervical cancer was correlated with the proliferation and invasion activity of the tumor (P 0.05).Conclusion the high expression of OPN and the low expression of sE-cadherin in serum of patients with cervical cancer have direct correlation with tumor proliferation and invasion.
【作者單位】： �？谑袐D幼保健院婦產(chǎn)科;
【分類號】：R737.33

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