發(fā)布時(shí)間：2018-03-30 07:40

  本文選題：先天性心臟病　切入點(diǎn)：頸項(xiàng)透明層厚度　出處：《中國(guó)現(xiàn)代醫(yī)學(xué)雜志》2017年13期

【摘要】：目的探討于孕早期頸項(xiàng)透明層厚度(NT)、三尖瓣反流(TR)與動(dòng)脈導(dǎo)管(DV)和孕中期母體血清甲胎蛋白(AFP)、游離β絨毛膜促性腺激素(free-β-HCG)檢測(cè)在篩查胎兒先天性心臟病(CHD)中的意義和作用。方法對(duì)2010年12月-2016年2月于該院就診的單胎孕婦共2 632例,于孕11~14周時(shí)進(jìn)行產(chǎn)前診斷時(shí)行超聲檢查,3項(xiàng)超聲檢查均異常視為高危;所有孕婦亦于孕15~21周進(jìn)行母血清標(biāo)志物AFP和free-β-HCG測(cè)定,風(fēng)險(xiǎn)率≥1/270為血清學(xué)篩查高危。并對(duì)所有孕婦進(jìn)行隨訪。對(duì)超聲檢查高危、血清學(xué)篩查高危與兩者聯(lián)合篩查均高危結(jié)果進(jìn)行比較。結(jié)果分別比較超聲檢查、血清學(xué)檢測(cè)2種檢測(cè)結(jié)果,差異無統(tǒng)計(jì)學(xué)意義;聯(lián)合篩查與超聲檢查、血清學(xué)檢測(cè)結(jié)果比較,差異有統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論胎兒NT、TR、DV及母體血清學(xué)檢測(cè)異常提示胎兒存在潛在的CHD的風(fēng)險(xiǎn),超聲檢查聯(lián)合血清學(xué)檢查能提高CHD的檢出率。
[Abstract]:Objective to investigate the clinical significance of detecting the thickness of transparent layer of cervical tract (NTT), tricuspid regurgitation (TRT) and ductus arteriosus (DVV), maternal serum AFP (AFP) and free 尾 chorionic gonadotropin (free- 尾 -HCG) in the screening of fetal congenital heart disease (CHD) in the first trimester of pregnancy. Methods from December 2010 to February 2016, a total of 2,632 single-child pregnant women were admitted to the hospital. At the 14th week of gestation, 3 items of ultrasound examination were regarded as high risk, and the maternal serum markers AFP and free- 尾 -HCG were measured at 1521 weeks of gestation. The risk rate 鈮，

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