本文選題：妊娠期高血壓疾病　切入點：晚發(fā)型子癇前期　出處：《延安大學》2017年碩士論文

【摘要】：目的:本研究對晚發(fā)型子癇前期患者及正常分娩孕婦的甲狀腺激素、凝血功能、血小板功能相關(guān)指標及SOD、MAO值進行了比較和分析,探討參與晚發(fā)型子癇前期發(fā)病的部分可能因素;并對其腎功能的相關(guān)指標進行監(jiān)測,分析其變化的臨床意義。方法:選取138例于2015年10月至2017年2月在我院產(chǎn)科住院分娩的晚發(fā)型子癇前期患者作為實驗組,其中輕度子癇前期組69例,重度子癇前期組69例;隨機選取于我院同期住院分娩、無任何合并癥與并發(fā)癥的70例正常分娩孕婦作為對照組。記錄所有孕婦的一般資料;血清TSH、FT4及FT3水平;SOD及MAO值;PT、APTT、TT及FIB值;MPV、PDW及PLT值;s Cr、UA、Cys C及β2-MG的值。采用統(tǒng)計學軟件SPSS 22.0對所收集的資料進行分析。結(jié)果:1.三組研究對象甲狀腺激素指標的比較:子重組TSH值較子輕組、對照組明顯升高,FT4、FT3值均明顯降低。2.三組研究對象SOD、MAO水平的比較:子重組SOD值較子輕組和對照組均明顯降低,且子輕組與對照組比較時SOD值亦明顯降低。子重組的MAO值明顯低于對照組。3.三組研究對象凝血功能的比較:子輕組PT值較對照組明顯減低,TT值明顯升高。子重組PT、FIB值均明顯低于子輕組和對照組,TT值明顯高于子輕組和對照組。子重組的APTT值明顯低于子輕組。4.三組研究對象血小板功能相關(guān)指標的比較:子重組MPV和PDW值均明顯高于子輕組及對照組,而PLT值明顯低于子輕組及對照組。5.三組研究對象腎功能指標的比較:子輕組的UA及Cys C值均明顯高于對照組。子重組s Cr、UA、Cys C及β2-MG值均明顯高于子輕組和對照組。結(jié)論:1.晚發(fā)型子癇前期的發(fā)生可能與孕婦體內(nèi)TSH水平升高、FT4及FT3水平低下有關(guān)。2.晚發(fā)型子癇前期的發(fā)生可能與機體抗氧化能力減弱或氧化應(yīng)激激活有關(guān)。3.機體凝血功能亢進、血小板消耗可能在晚發(fā)型子癇前期的疾病進展過程中起到一定的作用。4.UA及Cys C值能夠更加敏感的反映腎功能的損害。若能夠聯(lián)合s CR、UA、Cys C及β2-MG值的改變來衡量腎功能,可以更加敏感的發(fā)現(xiàn)早期腎損害。
[Abstract]:Objective: to compare and analyze the thyroid hormones, coagulation function, platelet function and SODU Mao in patients with late onset preeclampsia and normal delivery pregnant women, and to explore some possible factors involved in the onset of late onset preeclampsia. The clinical significance of the changes was analyzed. Methods: 138 patients with late-onset preeclampsia who were delivered in our hospital from October 2015 to February 2017 were selected as experimental group. There were 69 cases of mild preeclampsia group and 69 cases of severe preeclampsia group. Serum TSHT FT 4 and FT3 levels sod and MAO values PTT TT and FIB values of MPVU PDW and PLT C and 尾 2-MG. The collected data were analyzed with the statistical software SPSS 22.0.Results 1.The thyroid hormone indexes of the three groups were compared as follows: (1) the indexes of thyroid hormones in the three groups were compared as follows: (1) the indexes of thyroid hormones in the three groups were compared as follows: (1) the indexes of thyroid hormones in the three groups of subjects were compared as follows:. The TSH value of the group was lower than that of the subgroup. Compared with the light group and the control group, the SOD values of the three groups were significantly lower than those of the light group and the control group, and the level of SOD4 / MAO in the three groups was significantly lower than that in the light group and the control group, and there was no significant difference between the control group and the control group. Compared with the control group, the SOD value of the sub-light group was significantly lower than that of the control group, and the MAO value of the subgroup was significantly lower than that of the control group .3.The coagulation function of the three groups was compared. The PT value of the sub-light group was significantly lower than that of the control group, and the TT value of the subgroup was significantly increased. The APTT value of the subgroup was significantly lower than that of the light group and control group, and the APTT value of the subgroup was significantly lower than that of the subgroup .4.Compared with the three groups, the MPV and PDW values of the three groups were all clear. It was significantly higher than that in the light group and the control group. However, the PLT value was significantly lower than that in the subgroup and the control group. The comparison of renal function indexes among the three groups: the UA and Cys C values of the subgroup were significantly higher than those of the control group, and the values of the subrecombinant sCRA UACys C and 尾 2-MG were significantly higher than those of the subgroup and the control group. Conclusion 1. The occurrence of late-onset preeclampsia may be related to the increase of TSH level and the low levels of FT4 and FT3 in pregnant women. The occurrence of late-onset preeclampsia may be related to the decrease of antioxidant capacity or the activation of oxidative stress. Platelet consumption may play a role in the progression of late onset preeclampsia. 4. The values of UA and Cys C can more sensitively reflect the impairment of renal function. Early renal damage can be detected more sensitively.
【學位授予單位】：延安大學
【學位級別】：碩士
【學位授予年份】：2017
【分類號】：R714.244

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