本文選題：氯米芬　切入點(diǎn)：來曲唑　出處：《臨床軍醫(yī)雜志》2016年04期

【摘要】：目的探討枸櫞酸氯米芬(CC)和來曲唑(LE)在多囊卵巢綜合征(PCOS)不孕患者中促排卵的作用。方法選擇2014年1月至2015年12月在上海市沃德醫(yī)療中心就診的PCOS不孕患者,隨機(jī)分為研究組(n=120)和對照組(n=115)。研究組和對照組分別在月經(jīng)第3天開始應(yīng)用LE 5 mg和CC 100 mg促排卵,應(yīng)用5 d后停藥,并在至少一個(gè)卵泡直徑達(dá)20 mm時(shí)注射10 000 IU的h CG。比較兩組患者直徑≥14 mm卵泡(優(yōu)勢卵泡)數(shù)、直徑≥18 mm卵泡數(shù)及注射h CG時(shí)子宮內(nèi)膜厚度、促排卵后內(nèi)分泌指標(biāo)、周期妊娠率等。結(jié)果研究共納入235例PCOS患者,給予LE促排卵(研究組)的120例中,39例妊娠,周期妊娠率為32.5%,給予CC促排卵(對照組)的115例中,15例妊娠,周期妊娠率為13.0%,兩組間比較差異有統(tǒng)計(jì)學(xué)意義(P0.01)。注射h CG時(shí),對照組子宮內(nèi)膜厚度(9.4±0.2)mm,高于觀察組的(8.0±0.3)mm,差異有統(tǒng)計(jì)學(xué)意義(P0.05)。促排卵后,對照組組患者的血清雌激素、孕激素和黃體生成素水平均高于觀察組,而FSH水平和AMH水平低于觀察組,差異均有統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論與對照組比較,應(yīng)用LE對PCOS不孕患者進(jìn)行促排卵治療,對子宮內(nèi)膜影響小,周期妊娠率高。
[Abstract]:Objective to investigate the role of clomiphene citrate (CCC) and letrozolide (letrozolide) in promoting ovulation in infertile patients with polycystic ovary syndrome (PCOS). Methods PCOS infertile patients were selected from January 2014 to December 2015 in Shanghai Ward Medical Center. The study group and the control group were randomly divided into two groups: the control group and the control group were treated with 5 mg of le and 100 mg of CC on the 3rd day of menstruation. At least one follicle with diameter of 20 mm was injected with 10 000 IU of hCG.The number of follicles (dominant follicles) 鈮，

本文編號：1677761