本文選題：產(chǎn)后抑郁　切入點：基因多態(tài)性　出處：《解放軍醫(yī)學(xué)雜志》2017年06期

【摘要】：目的研究腦源性神經(jīng)營養(yǎng)因子(BDNF)基因多態(tài)性與剖宮產(chǎn)產(chǎn)婦產(chǎn)后抑郁(PPD)的相關(guān)性。方法選擇2014年2月-2015年2月在中南大學(xué)湘雅三醫(yī)院和湖南省婦幼保健醫(yī)院進行椎管內(nèi)麻醉下剖宮產(chǎn)手術(shù)的產(chǎn)婦360例,記錄患者的一般資料。應(yīng)用愛丁堡產(chǎn)后抑郁量表(EPDS)分別對產(chǎn)婦產(chǎn)前1d、產(chǎn)后第42天的精神狀態(tài)進行評估,以EPDS評分≥13分作為產(chǎn)后抑郁的評定界值。采用Sequenom?Mass Array SNP對BDNF基因G712A、rs56164415、rs11030100、rs11030101、rs6265位點的基因型進行測定,分析產(chǎn)婦一般資料、不同基因型與產(chǎn)后抑郁的相關(guān)性。結(jié)果本組360例產(chǎn)婦產(chǎn)后抑郁的發(fā)生率為7.2%。Logistic回歸分析顯示,孕期壓力大、孕期心情差、圍產(chǎn)期單核細胞數(shù)值升高、產(chǎn)前抑郁情緒是剖宮產(chǎn)后抑郁的危險因素,而BDNF基因rs6265位點突變是剖宮產(chǎn)產(chǎn)后抑郁的保護因素(P0.05)。BDNF基因G712A、rs11030101、rs11030100、rs56164415位點突變與產(chǎn)后抑郁的發(fā)生無關(guān)(P0.05),且其單倍體型與產(chǎn)后抑郁也無關(guān)。結(jié)論攜帶BDNF rs6265CC基因型、孕期壓力大、孕期心情差、圍產(chǎn)期單核細胞數(shù)值升高以及產(chǎn)前抑郁情緒是產(chǎn)后抑郁的危險因素。
[Abstract]:Objective to study the association of BDNFgene polymorphism with postpartum depression (PPDD) in cesarean section women. Methods vertebrae were selected from February 2014 to February 2015 in Xiangya third Hospital of Central South University and Hunan Maternal and Child Health Hospital. 360 cases of cesarean section under intravascular anesthesia, The general data of the patients were recorded. The mental state of the parturient was evaluated by the Edinburgh postpartum Depression scale (EPDS) on the 1st day and the 42nd day of postpartum respectively. The EPDS score 鈮，

本文編號：1677413