本文選題：艾滋病　切入點：妊娠婦女　出處：《中國艾滋病性病》2017年09期

【摘要】：目的探討克力芝在艾滋病病毒(HIV)感染妊娠婦女中抗病毒治療(ART)的效果和安全性。方法采集2011年1月至2016年6月,在北京佑安醫(yī)院性病艾滋病門診,接受基于克力芝的三聯(lián)抗病毒治療的HIV感染妊娠婦女的臨床資料,分析ART的療效與安全性。結(jié)果 210例HIV感染孕婦基線時CD4~+T淋巴細胞(簡稱CD4細胞)計數(shù)為(365±171)個/μL,治療24周時CD4細胞計數(shù)為(522±198)個/μL,治療48周時CD4細胞計數(shù)為(546±203)個/μL,與基線相比差異有統(tǒng)計學(xué)意義(P均0.05);病毒載量檢測不到者所占的比例在基線、24周和48周時分別為12.4%、91.0%和96.7%,與基線相比差異有統(tǒng)計學(xué)意義(P均0.05);胃腸道反應(yīng)、貧血和血脂異常發(fā)生率分別為16.2%、12.4%和7.6%,無嚴重不良反應(yīng)發(fā)生。結(jié)論基于克力芝的三聯(lián)抗病毒治療對于HIV感染孕婦療效顯著,安全性良好,可在HIV感染妊娠婦女中進一步推廣。
[Abstract]:Objective to investigate the efficacy and safety of anti-viral therapy (ART) in pregnant women infected with HIV / AIDS (HIV / AIDS). Methods from January 2011 to June 2016, Cleidge was collected from the STD / AIDS clinic of Beijing Youan Hospital. Clinical data of pregnant women with HIV infection who received triple antiviral therapy based on Clariz, Results the counts of CD4 ~ T lymphocytes (CD4 cells) in 210 pregnant women with HIV infection were 365 鹵171 / 渭 L at baseline, 522 鹵198 / 渭 L on 24 weeks after treatment, and 546 鹵203 on 48 weeks after treatment. / 渭 L, the difference was statistically significant (P < 0.05) compared with baseline, the proportion of patients whose viral load could not be detected was 12.41.0% and 96.7% at 24 and 48 weeks of baseline, respectively, and the difference was statistically significant compared with baseline (P < 0.05), gastrointestinal reaction, Gastrointestinal reaction, Gastrointestinal reaction, Gastrointestinal reaction, Gastrointestinal reaction, Gastrointestinal reaction, Gastrointestinal reaction, Gastrointestinal reaction, Gastrointestinal reaction, Gastrointestinal reaction, The incidence of anemia and dyslipidemia were 12.4% and 7.6%, respectively. There was no serious adverse reaction. Conclusion the triple antiviral therapy based on Claridum is effective and safe for pregnant women with HIV infection, and can be further popularized in pregnant women infected with HIV.
【作者單位】： 首都醫(yī)科大學(xué)附屬北京佑安醫(yī)院感染中心;
【分類號】：R714.251
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本文編號：1677142