本文選題：骨橋蛋白　切入點：卵巢癌　出處：《中國婦產(chǎn)科臨床雜志》2015年06期

【摘要】：目的探討骨橋蛋白(osteopontin,OPN)與卵巢癌紫杉醇化療耐藥的關系及臨床意義。方法收集北京市多家三甲醫(yī)院2013年3月至10月卵巢上皮癌組織72例,根據(jù)三磷酸腺苷腫瘤體外藥物敏感性檢測(ATP-TCA)結(jié)果將其分為紫杉醇敏感組(49例)、中度敏感組(15例)和耐藥組(8例)。采用免疫印跡法檢測各組OPN的表達。結(jié)果 1耐藥組OPN的表達(2.027±0.402)顯著高于敏感組(0.603±0.271)及輕度敏感組(1.173±0.350),三組比較,差異有統(tǒng)計學意義(P=0.000),且其表達與紫杉醇敏感度系數(shù)(SI)呈正相關(r=0.459,P=0.000);2 OPN在Ⅲ期卵巢癌組織中的表達明顯高于Ⅰ、Ⅱ期(P=0.029),G3級表達顯著高于G1、G2級(P=0.006),但不同病理類型比較,差異無統(tǒng)計學意義(P0.05)。結(jié)論 OPN表達上調(diào)與卵巢癌紫杉醇化療耐藥有一定相關性,且與腫瘤臨床分期、病理分級密切相關。
[Abstract]:Objective to investigate the relationship between osteopontinin (OPN) and paclitaxel resistance in ovarian cancer and its clinical significance. Methods 72 cases of ovarian epithelial carcinoma were collected from March to October 2013 in several third Class A hospitals in Beijing. According to the in vitro drug sensitivity test of adenosine triphosphate tumor, it was divided into paclitaxel sensitive group (49 cases) and moderately sensitive group (15 cases) and drug-resistant group (8 cases). Western blot was used to detect the expression of OPN in each group. The expression of OPN in the drug group (2.027 鹵0.402) was significantly higher than that in the sensitive group (0.603 鹵0.271) and the mild sensitive group (1.173 鹵0.350). There was a positive correlation between the expression of OPN and the sensitivity coefficient of paclitaxel. The expression of OPN in stage 鈪，

本文編號：1660438