發(fā)布時(shí)間：2018-03-24 09:55

  本文選題：宮頸癌　切入點(diǎn)：放射治療　出處：《山西醫(yī)科大學(xué)》2017年碩士論文

【摘要】：目的:山西省是我國宮頸癌高發(fā)的地區(qū)之一,本研究將470例宮頸癌患者作為研究對(duì)象,比較不同放射方式(三維適形放療與調(diào)強(qiáng)放療)治療后對(duì)患者臨床療效影響的差異。方法:搜集201205-201505期間在山西省腫瘤醫(yī)院就診的宮頸癌的470份患者病例,分析三維適形放療和調(diào)強(qiáng)放療治療宮頸癌患者的臨床表現(xiàn)。應(yīng)用SPSS17.0軟件進(jìn)行統(tǒng)計(jì)學(xué)分析,統(tǒng)計(jì)方法包括t檢驗(yàn),χ2檢驗(yàn),來分析兩組在血液毒性反應(yīng)、生存與復(fù)發(fā)和放射性副反應(yīng)等方面的差異。結(jié)果:在三維適性放療組中,出現(xiàn)1級(jí)毒性反應(yīng)71例(31.4%),2級(jí)毒性反應(yīng)53例(23.5%),3級(jí)毒性反應(yīng)45例(19.9%);在調(diào)強(qiáng)放療組中,出現(xiàn)1級(jí)毒性反應(yīng)78例(31.9%),2級(jí)毒性反應(yīng)62例(25.4%),3級(jí)毒性反應(yīng)29例(11.9%);僅3級(jí)毒性反應(yīng)兩組具有差異性,而兩組都無4級(jí)毒性反應(yīng)的發(fā)生。同時(shí),血紅蛋白(Hb)和紅細(xì)胞(RBC)調(diào)強(qiáng)放療組顯著高于三維適性放療組,而血小板(PLT)和白細(xì)胞(WBC)處于同一水平。三維適形放射治療組復(fù)發(fā)63例(27.9%),44例為局部盆腔復(fù)發(fā),19例為遠(yuǎn)處復(fù)發(fā);調(diào)強(qiáng)放射治療組復(fù)發(fā)42例(17.2%),29例為局部盆腔復(fù)發(fā),13例為遠(yuǎn)處復(fù)發(fā),兩組之間統(tǒng)計(jì)學(xué)均無顯著性差異(P0.05)。三維適形放射治療組放射性直腸炎發(fā)生率是20.8%,顯著高于調(diào)強(qiáng)放射治療組的發(fā)生率(P0.05),其中間歇性便急反應(yīng)癥狀明顯,差異顯著。結(jié)論:1)三維適形放射治療組和調(diào)強(qiáng)放射治療組都會(huì)產(chǎn)生血液毒性反應(yīng),降低血小板含量和減少白細(xì)胞數(shù)量。2)直腸反應(yīng)發(fā)生率三維適形放射治療組顯著高于調(diào)強(qiáng)放射治療組。3)三維適形放射治療組間歇性便急的直腸炎反應(yīng)的發(fā)生顯著高于調(diào)強(qiáng)放射治療組,而其它反應(yīng)癥狀兩組均存在發(fā)生。
[Abstract]:Objective: Shanxi Province is one of the areas with high incidence of cervical cancer in China. In this study, 470 patients with cervical cancer were studied. To compare the effects of three dimensional conformal radiotherapy (3D conformal radiotherapy) and intensity modulated radiotherapy (IMRT) on the clinical efficacy of patients with cervical cancer. Methods: 470 cases of cervical cancer in Shanxi Provincial Cancer Hospital from 201205-201505 were collected. Three dimensional conformal radiotherapy and intensity modulated radiotherapy were used to analyze the clinical manifestations of cervical cancer patients. The statistical methods including t test and 蠂 2 test were used to analyze the blood toxicity of the two groups. Results: there were 71 cases of grade 1 toxic reaction and 53 cases of grade 2 toxic reaction in the three dimensional adaptive radiotherapy group. There were 45 cases of grade 3 toxic reaction in the intensity modulated radiotherapy group, while in the intensity modulated radiotherapy group, there were 45 cases of the grade 3 toxic reaction. There were 78 cases of grade 1 toxic reaction and 62 cases of grade 2 toxic reaction. There were 29 cases of grade 3 toxicity reaction in 29 cases, only grade 3 toxicity reaction had difference between the two groups, but there was no grade 4 toxic reaction in both groups. At the same time, there was no grade 4 toxic reaction in both groups. Hemoglobin HB) and RBC were significantly higher in the intensity modulated radiotherapy group than in the three dimensional conformal radiotherapy group, but PLT and WBCwere at the same level. In the 3D conformal radiotherapy group, there were 63 recurrence cases (27.9C) and 44 cases local pelvic recurrence (19 cases were distant recurrence). In the intensity modulated radiotherapy group, there were 42 cases of recurrence and 29 cases of local pelvic recurrence. 13 cases were distant recurrence. There was no significant difference between the two groups (P 0.05). The incidence of radiation proctitis in the three dimensional conformal radiotherapy group was 20. 8, which was significantly higher than that in the intensity modulated radiation therapy group (P 0. 05). Conclusion: Three-dimensional conformal radiation therapy group and intensity modulated radiation group can produce blood toxicity reaction. Reduction of platelet content and leukocyte count. 2) incidence of rectal reaction in 3D conformal radiotherapy group was significantly higher than that in intensity modulated radiotherapy group. 3) intermittent colitis response was significantly higher in 3D conformal radiotherapy group. In the intensity modulated radiotherapy group, Other reaction symptoms occurred in both groups.
【學(xué)位授予單位】：山西醫(yī)科大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2017
【分類號(hào)】：R730.55;R737.33

【參考文獻(xiàn)】

相關(guān)期刊論文 前10條

1 李雅玲;郜霞;王艷花;宋家武;;山西省不同地區(qū)女性人乳頭瘤病毒感染55582例現(xiàn)狀分析[J];中國藥物與臨床;2016年11期

2 陳嫣;王靜;王子毅;許一諾;洪婷;;宮頸腺癌的診治及研究進(jìn)展[J];腫瘤藥學(xué);2016年05期

3 田源;張紅志;;腫瘤放射治療技術(shù)進(jìn)展[J];中華結(jié)直腸疾病電子雜志;2016年04期

4 唐嘉;王華英;;宮頸癌放射治療[J];上海醫(yī)藥;2016年11期

5 朱佳妮;王東卓;劉宗唐;;宮頸癌篩查技術(shù)研究進(jìn)展[J];中國實(shí)用婦科與產(chǎn)科雜志;2016年06期

6 李威;王德征;沈成鳳;張穎;江國虹;;天津市2007-2013年宮頸癌發(fā)病趨勢(shì)及流行特征分析[J];中華流行病學(xué)雜志;2016年05期

7 王惠芬;毛熙光;;對(duì)宮頸癌及宮頸癌前病變進(jìn)行早期篩查的新進(jìn)展[J];當(dāng)代醫(yī)藥論叢;2016年07期

8 劉慧強(qiáng);;我國宮頸癌流行病學(xué)特征和高危因素分析[J];中國婦幼保健;2016年06期

9 李鵬程;馮藝蘭;范子煊;郎錦義;;宮頸癌體外放射治療技術(shù)進(jìn)展[J];腫瘤預(yù)防與治療;2016年01期

10 黃曼妮;安菊生;杜霄勐;;宮頸癌放射治療的研究進(jìn)展[J];中華婦幼臨床醫(yī)學(xué)雜志(電子版);2016年01期

相關(guān)碩士學(xué)位論文 前1條

1 齊健;不同放射源輻照宮頸癌細(xì)胞的紅外光譜研究[D];鄭州大學(xué);2009年

，

本文編號(hào)：1657788