本文選題：多囊卵巢綜合征(PCOS)　切入點：優(yōu)質(zhì)胚胎　出處：《生殖與避孕》2016年04期 　論文類型：期刊論文

【摘要】：目的:探討多囊卵巢綜合征(PCOS)患者在優(yōu)質(zhì)凍融胚胎移植(FET)后是否有更高的妊娠丟失率。方法:回顧性分析診斷為PCOS并初次接受體外受精-胚胎移植(IVF-ET)或卵胞質(zhì)內(nèi)單精子注射(ICSI)FET的患者,選擇移植凍融胚胎中含有卵裂期優(yōu)質(zhì)胚胎且生化妊娠陽性的157個周期的臨床資料為PCOS組,同期年齡、體質(zhì)量指數(shù)(BMI)、不孕年限與PCOS組匹配的、因單純輸卵管因素接受IVF-ET助孕治療并生化妊娠陽性的389個FET周期的臨床資料為對照組,比較組間的生化妊娠丟失率、早期流產(chǎn)率、晚期流產(chǎn)率、活產(chǎn)率。結(jié)果:在接受優(yōu)質(zhì)卵裂期FET的PCOS患者妊娠后,生化妊娠丟失率、早期流產(chǎn)率、晚期流產(chǎn)率、活產(chǎn)率與對照組相比(8.28%vs 5.14%、7.64%vs 8.13%、6.94%vs 5.15%、79.86%vs 84.28%),差異無統(tǒng)計學(xué)意義(P0.05)。結(jié)論:在固定胚胎質(zhì)量這個重要的影響妊娠早期丟失的影響因子的基礎(chǔ)上,排除年齡、BMI、自然流產(chǎn)次數(shù)、是否多胎妊娠、移植日內(nèi)膜厚度等影響因素的干擾,患PCOS并不增加IVF/ICSI的生化妊娠丟失率和臨床妊娠流產(chǎn)率。
[Abstract]:Objective: to investigate whether there is a higher rate of pregnancy loss in patients with polycystic ovary syndrome (PCOS) after high quality frozen-thawed embryo transfer (FET). Methods: a retrospective analysis was made of PCOS and IVF-ETs or in vitro fertilization-embryo transfer IVF-ETs (IVF-ETs) or in the cytoplasm of oocytes in patients with polycystic ovary syndrome (PCOS). In patients with ICSIFET, The clinical data of 157 cycles of frozen and thawed embryos with good cleavage and positive biochemical pregnancy were selected as PCOS group, age, body mass index (BMI), infertility years matched with PCOS group. The clinical data of 389 FET cycles which were treated with IVF-ET assisted pregnancy therapy and positive biochemical pregnancy were used as control group. The rate of loss of biochemical pregnancy, early abortion rate and late abortion rate were compared between the two groups. Results: after pregnancy of PCOS patients receiving FET, the rate of loss of biochemical pregnancy, early abortion rate, late abortion rate, The rate of live delivery was 8.28 vs 5.14 7.64 vs 8.136.94 vs 5.159.86 vs 84.285.Conclusion: on the basis of immobilization of embryo quality, which is an important factor affecting the loss of early pregnancy, the age BMIs, the number of spontaneous miscarriages, the number of spontaneous abortions, and the number of multiple pregnancies are excluded. PCOS did not increase the rate of biochemical pregnancy loss and clinical pregnancy abortion rate of IVF/ICSI due to the interference of intimal thickness and other factors.
【作者單位】： 河南省人民醫(yī)院生殖中心;
【基金】：河南省重點科技攻關(guān)計劃項目,項目號:142102310077
【分類號】：R714.8

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