本文選題：控制性超促排卵(COH)　切入點(diǎn)：卵巢慢反應(yīng)　出處：《中華生殖與避孕雜志》2017年09期 　論文類(lèi)型：期刊論文

【摘要】：目的探討控制性超促排卵(COH)過(guò)程中發(fā)生卵巢慢反應(yīng)可能的相關(guān)因素。方法回顧性分析2014年1月—2016年1月期間于蘭州大學(xué)第一醫(yī)院、新疆佳音醫(yī)院、青海省人民醫(yī)院、銀川市婦幼保健院、廣西玉林市婦幼保健院進(jìn)行促性腺激素釋放激素激動(dòng)劑(GnRH-a)長(zhǎng)方案體外受精-胚胎移植(IVF-ET)的144例卵巢慢反應(yīng)患者的臨床資料,與132例卵巢正常反應(yīng)患者(正常對(duì)照組)進(jìn)行對(duì)比。結(jié)果與正常對(duì)照組相比,慢反應(yīng)組患者體質(zhì)量指數(shù)(BMI)、促甲狀腺激素(TSH)較高,降調(diào)節(jié)及促排卵時(shí)間較長(zhǎng),促性腺激素(Gn)使用后7d平均卵泡直徑偏小,雌二醇(E_2)、黃體生成素(LH)低,hCG注射日E_2低,IVF雙原核(2PN)卵裂率較高,臨床妊娠率低,差異均有統(tǒng)計(jì)學(xué)意義(P0.05)�；颊吣挲g、不孕年限、基礎(chǔ)卵泡刺激素(FSH)、LH、催乳素(PRL)、E_2、基礎(chǔ)卵泡數(shù)、hCG注射日孕酮(P)、獲卵率、胚胎質(zhì)量、胚胎種植率、流產(chǎn)率、宮外孕率、繼續(xù)妊娠率及取消移植率組間均無(wú)統(tǒng)計(jì)學(xué)差異(P0.05)。結(jié)論卵巢慢反應(yīng)可能與患者BMI過(guò)高、甲狀腺功能降低及GnRH-a過(guò)度抑制相關(guān),較長(zhǎng)的Gn天數(shù)仍可使慢反應(yīng)患者獲得較好的妊娠結(jié)局。
[Abstract]:Objective to investigate the related factors of ovarian slow response in the process of controlled hyperstimulation of ovulation (COH). Methods from January 2014 to January 2016, a retrospective analysis was made at the first Hospital of Lanzhou University, Jiayin Hospital of Xinjiang, and the people's Hospital of Qinghai Province. Clinical data of 144 patients with ovarian slow reaction in Yinchuan Maternal and Child Health Hospital and Yulin City Maternal and Child Health Hospital, Guangxi, who underwent in vitro fertilization and embryo transfer IVF-ETs with gonadotropin releasing hormone agonist (GnRH-a), a long-term gonadotropin releasing hormone agonist (GnRH-a). Results compared with the normal control group, the body mass index (BMI) and thyrotropin (TSH) of the slow response group were higher, and the time of lowering regulation and ovulation promoting were longer. The mean follicle diameter of gonadotropin Gnn was small 7 days after administration, the average follicular diameter was small, estradiol E _ 2H _ 2 and luteinizing hormone LH) were lower. The cleavage rate was higher and the clinical pregnancy rate was lower on the day of E2 low IVF double prokaryotic 2PN) on the day of injection of E2 low IVF, the difference was statistically significant (P 0.05). Basal follicle stimulating hormone (FSH), prolactin prolactin (PRL), prolactin (PRL), prolactin (PRL), prolactin (PRL), prolactin (PRL), basal follicle number (hCG), progesterone (P), egg acquisition rate, embryo quality, embryo implantation rate, abortion rate, ectopic pregnancy rate, There was no significant difference in the rate of continuous pregnancy and cancellation of transplantation between the two groups. Conclusion the slow ovarian response may be related to the high BMI, the decrease of thyroid function and the excessive inhibition of GnRH-a, and the longer days of Gn can still lead to a better pregnancy outcome in the patients with slow response.
【作者單位】： 蘭州大學(xué)第一醫(yī)院生殖醫(yī)學(xué)專(zhuān)科醫(yī)院;新疆佳音醫(yī)院;青海省人民醫(yī)院;廣西玉林市婦幼保健院;銀川市婦幼保健院;
【分類(lèi)號(hào)】：R714.8

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