本文選題：子官腺肌病　切入點：子宮結合帶　出處：《浙江大學》2014年碩士論文　論文類型：學位論文

【摘要】：目的：研究酪氨酸激酶受體A(tyrosine kinase receptor A, TrkA)在子宮腺肌病(Adenomyosis, AM)患者子宮結合帶(the uterine junctional zone, JZ)中的表達及其與痛經(jīng)和血清CA125水平的關系,探討TrkA與子宮腺肌病痛經(jīng)的關系。 方法：收集24例因子宮腺肌病行子宮全切或次全切除的病例作為研究組(AM組),其中處于子宮內(nèi)膜增生期15例,分泌期9例；收集同期因子宮肌瘤行子宮全切或次全切除的病例作為對照組,其中處于子宮內(nèi)膜增生期9例,分泌期6例。術前通過視覺模擬評分法(visual analogue scale/score, VAS)進行疼痛程度評分,用免疫組化SP法檢測兩組子宮內(nèi)膜和JZ組織中TrkA的表達,比較JZ組織中增生期與分泌期TrkA的表達差異,分析其與痛經(jīng)的關系,及與血清CA125水平的相關性。 結果： 1.TkrA在子宮內(nèi)膜及JZ組織中均有表達。 2.TrkA在AM組內(nèi)膜和JZ中的表達均高于對照組,差異具有統(tǒng)計學意義(P0.05)；TrkA在AM組和對照組JZ中的表達均高于內(nèi)膜,差異具有統(tǒng)計學意義(P0.05)。 3.在子宮內(nèi)膜增生期與分泌期,TrkA在子宮腺肌病患者的JZ中均可見表達,在增生期的表達高于分泌期,且差異具有統(tǒng)計學意義(P0.05)。 4.在AM組JZ中,隨著疼痛程度的增加,TrkA的表達逐漸增加,兩者具有顯著正相關性(r=0.571,P0.05)。 5.在AM組JZ中,隨著血清CA125水平的增加,TrkA的表達逐漸增加,兩者具有顯著正相關性(r=0.678,P0.05)。 結論：子宮腺肌病中TrkA的表達明顯增加,且與疼痛程度呈正相關,提示TrkA可能參與子宮腺肌病痛經(jīng)的發(fā)生。
[Abstract]:Objective: to study the expression of tyrosine kinase receptor A (TrkA) in the uterine junctional zonein of adenomyosis and its relationship with the levels of dysmenorrhea and serum CA125, and to explore the relationship between TrkA and dysmenorrhea in adenomyosis. Methods: Twenty-four patients with adenomyosis underwent total or subtotal hysterectomy as study group. 15 cases were in endometrial hyperplasia and 9 cases were in secretory phase. The patients who underwent hysterectomy or subtotal hysterectomy during the same period were collected as the control group, including 9 cases in endometrial hyperplasia and 6 cases in secretory phase. The pain degree was evaluated by visual analogue scale / score (vas) before operation. Immunohistochemical SP method was used to detect the expression of TrkA in endometrium and JZ tissues. The difference of TrkA expression in proliferative phase and secretory phase was compared, and the relationship between TrkA expression and dysmenorrhea and serum CA125 level was analyzed. Results:. 1. TkrA was expressed in both endometrium and JZ tissues. 2. The expression of TrkA in the endometrium and JZ of AM group was higher than that in the control group, and the difference was statistically significant (P 0.05). The expression of TrkA in JZ of AM group and control group was higher than that of the control group, and the difference was statistically significant. 3. TrkA expression was found in both proliferative and secretory stages of endometrium in patients with adenomyosis. The expression of TrkA in proliferative phase was higher than that in secretory phase, and the difference was statistically significant (P 0.05). 4. In AM group, the expression of TrkA increased with the increase of pain, and there was a significant positive correlation between them. 5. In AM group, the expression of TrkA increased with the increase of serum CA125 level, and there was a significant positive correlation between them. Conclusion: the expression of TrkA is significantly increased in adenomyosis, and is positively correlated with the degree of pain, suggesting that TrkA may be involved in the occurrence of dysmenorrhea in adenomyosis.
【學位授予單位】：浙江大學
【學位級別】：碩士
【學位授予年份】：2014
【分類號】：R711.71

【參考文獻】

相關期刊論文 前9條

1 陳瀅;王晶;楊賽花;;子宮腺肌癥痛經(jīng)發(fā)生因素臨床分析[J];華南國防醫(yī)學雜志;2012年01期

2 廖英;王建超;郭英;;血清CA125與子宮腺肌病相關性的分析與探討[J];遼寧中醫(yī)雜志;2012年12期

3 王文莉;段華;張穎;郭銀樹;成九梅;;子宮腺肌病PGP9.5、NGF的表達及其與痛經(jīng)的關系[J];首都醫(yī)科大學學報;2012年01期

4 彭超;周應芳;廖秦平;;子宮腺肌病患者痛經(jīng)強度與前列腺素的相關性研究[J];實用婦產(chǎn)科雜志;2006年01期

5 馬亦良;陳忠東;白軍;楊紅文;成明強;;NGF及其受體TrkA在子宮腺肌病中的表達及與痛經(jīng)的關系[J];現(xiàn)代生物醫(yī)學進展;2011年06期

6 徐影;趙艷暉;鄒穎剛;張煒e，

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