本文選題：粒細(xì)胞集落刺激因子　切入點(diǎn)：子宮內(nèi)膜厚度、形態(tài)　出處：《廣西醫(yī)科大學(xué)》2015年碩士論文　論文類(lèi)型：學(xué)位論文

【摘要】：目的：觀察并分析宮腔內(nèi)灌注粒細(xì)胞集落刺激因子(granulocyte colony-stimulating factor, G-CSF)對(duì)薄型子宮內(nèi)膜患者的子宮內(nèi)膜厚度、形態(tài)及子宮血流的影響,探討其對(duì)薄型子宮內(nèi)膜患者的應(yīng)用效果。方法：選取在廣西醫(yī)科大學(xué)第一附屬醫(yī)院生殖醫(yī)學(xué)研究中心己接受IVF-ET助孕未能成功,擬行FET助孕但使用人工周期準(zhǔn)備內(nèi)膜2個(gè)或2個(gè)周期以上反復(fù)B超檢測(cè)子宮內(nèi)膜厚度均小于7mm的薄型子宮內(nèi)膜患者30例,于再次行人工周期準(zhǔn)備內(nèi)膜的周期第13天(D13)、第16天(D16)分別加用宮腔內(nèi)灌注rhG-CSF150ug,共2次,分別于周期第13天(D13)、16天(D16)、19天(D19)的當(dāng)天行灌注前B超檢測(cè)子宮內(nèi)膜厚度、形態(tài)、子宮血流情況,血清E2水平及血常規(guī),比較：1.灌藥周期與灌藥前一周期D13、D16、D19子宮內(nèi)膜厚度,灌藥周期的D13與D16、D19子宮內(nèi)膜厚度；2.灌藥周期與灌藥前一周期D13、D19的血清E2水平,灌藥周期的D13與D19血清E2水平；3.灌藥周期的D13與D16、D19的子宮內(nèi)膜形態(tài)(A型、B型、C型)；4.灌藥周期的D13與D16、D19子宮內(nèi)膜下血流(Ⅰ型、Ⅱ型、Ⅲ型)；5.灌藥周期的D13與D16、D19子宮動(dòng)脈及子宮內(nèi)膜血流指數(shù)(RI、PI、S/D);6.灌藥前(D13)與灌藥后(D19)的血常規(guī)指標(biāo)。結(jié)果：1.子宮內(nèi)膜厚度比較：灌藥周期與灌藥前一周期的D13、D16、D19分別比較,D13、D16差異均無(wú)統(tǒng)計(jì)學(xué)意義(p0.05)；D19差異有統(tǒng)計(jì)學(xué)意義(p0.05)。灌藥周期的D13分別與D16、D19比較,D16差異無(wú)統(tǒng)計(jì)學(xué)意義(p0.05)；D19差異有統(tǒng)計(jì)學(xué)意義(p0.05)。2.血清E2水平比較：灌藥周期與灌藥前一周期的D13、D19分別比較,D13、D19差異均無(wú)統(tǒng)計(jì)學(xué)意義(p0.05)。灌藥周期的D13與D19組比較,差異有統(tǒng)計(jì)學(xué)意義(p0.05)。3.子宮內(nèi)膜形態(tài)A型、B型、C型指標(biāo)的比較：灌藥周期的D13與D16、D19分別比較,D16及D19的A型、B型、C型差異均無(wú)統(tǒng)計(jì)學(xué)意義(p0.05)。4.子宮內(nèi)膜下血流分型Ⅰ型、Ⅱ型、Ⅲ型指標(biāo)的比較：灌藥周期的D13與D16、D19分別比較,D16Ⅰ型、Ⅱ型、Ⅲ型差異均無(wú)統(tǒng)計(jì)學(xué)意義(p0.05)；D19Ⅰ型、Ⅱ型、Ⅲ型差異均有統(tǒng)計(jì)學(xué)意義(p0.05)。5.子宮動(dòng)脈及子宮內(nèi)膜血流RI、PI、S/D指標(biāo)比較：灌藥周期的D13子宮動(dòng)脈血流指數(shù)RI、PI、S/D與D16、D19的分別比較,差異均無(wú)統(tǒng)計(jì)學(xué)意義(p0.05)；灌藥周期的D13子宮內(nèi)膜血流指數(shù)RI、PI、S/D與D16、D19的分別比較,D16的RI、PI、S/D差異均無(wú)統(tǒng)計(jì)學(xué)意義(p0.05)；D19的RI、PI、S/D差異均有統(tǒng)計(jì)學(xué)意義(p0.05)。6.灌藥前(D13)與灌藥后(D19)的血常規(guī)指標(biāo)比較：D13與D19的外周血白細(xì)胞、中性粒細(xì)胞百分比、血小板計(jì)數(shù)相比,白細(xì)胞、中性粒細(xì)胞百分比、血小板比較差異均無(wú)統(tǒng)計(jì)學(xué)意義(p0.05)。結(jié)論：1.薄型子宮內(nèi)膜患者人工周期準(zhǔn)備內(nèi)膜時(shí)加用宮腔灌注rhG-CSF,可以改善其子宮內(nèi)膜厚度,可能增加子宮內(nèi)膜的血流2.宮腔灌注G-CSF手術(shù)簡(jiǎn)單、方便,安全
[Abstract]:Objective: to observe and analyze the effect of granulocyte colony-stimulating factor (G-CSF) on endometrial thickness, morphology and uterine blood flow in patients with thin endometrium. Methods: IVF-ET was used in the center of reproductive medicine of the first affiliated hospital of Guangxi Medical University. Thirty patients with thin endometrium whose thickness of endometrium were less than 7 mm were detected by B-mode ultrasound with FET assisted pregnancy but using artificial cycle to prepare endometrium for 2 or more cycles. On the 13th day of artificial cycle preparation of endometrium, on the 13th day, on the 16th day, the endometrium was infused with rhG-CSF150ug2, respectively. On the 13th day of the cycle, the thickness and morphology of endometrium were measured by B-mode ultrasound on the 13th day of the cycle, and on the 13th day of the cycle, the endometrium thickness and morphology were measured by B-mode ultrasound. Uterine blood flow, serum E _ 2 level and blood routine were compared. The endometrial thickness of D13D _ (16) D _ (19) and D13 and D _ (16) D _ (19) of the perfusion cycle were compared with that of the previous cycle. The serum E _ (2) level of the drug administration cycle was higher than that of D13 (D _ (13)) D _ (19). Serum E _ 2 levels of D13 and D19 in the perfusion cycle were 3.The endometrial morphology of D13 and D16 / D19 were as follows: type A and B, type C, and subendometrial blood flow (type 鈪，

本文編號(hào)：1627531