本文選題：多囊卵巢綜合征　切入點(diǎn)：高遷移率族蛋白A　出處：《中國實(shí)驗動物學(xué)報》2017年05期 　論文類型：期刊論文

【摘要】：目的研究PCOS易感基因Hmga2在子宮內(nèi)膜容受性和蛻膜化中的表達(dá)與調(diào)節(jié)。方法通過早期妊娠、延期著床與激活、人工蛻膜化、卵巢類固醇激素處理等實(shí)驗,利用q PCR、Western blot技術(shù),闡述Hmga2在子宮內(nèi)膜容受性中的作用。結(jié)果 Hmga2隨著妊娠表達(dá)量逐漸增加,著床點(diǎn)與非著床點(diǎn)相比表達(dá)量顯著升高,胚胎激活組比延遲著床表達(dá)量顯著增高,人工誘導(dǎo)蛻膜化與非蛻膜化比較表達(dá)顯著升高,Hmga2的表達(dá)與雌激素和孕激素呈正相關(guān),體內(nèi)受雌孕激素調(diào)節(jié)。結(jié)論表明Hmga2的表達(dá)與小鼠早期妊娠胚胎著床過程密切相關(guān),參與子宮內(nèi)膜蛻膜化過程,受活化胚泡和類固醇激素的影響。
[Abstract]:Objective to study the expression and regulation of PCOS susceptibility gene Hmga2 in endometrial receptivity and decidualization. Results the expression of Hmga2 in endometrium was increased with pregnancy, the expression of Hmga2 in implantation site was significantly higher than that in non-implantation site, and the expression of Hmga2 in embryo activated group was significantly higher than that in delayed implantation group. The expression of Hmga2 was positively correlated with estrogen and progesterone, and was regulated by estrogen and progesterone. Conclusion the expression of Hmga2 is closely related to the implantation process of mouse early pregnancy embryos. The process of decidualization of endometrium is affected by activation of blastocyst and steroid hormone.
【作者單位】： 中國農(nóng)業(yè)大學(xué)動物醫(yī)學(xué)院;山東大學(xué)生殖醫(yī)學(xué)研究中心;
【基金】：國家自然科學(xué)基金項目(編號:31572578)
【分類號】：R711.75
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本文編號：1620622