本文選題：唐氏篩查　切入點(diǎn)：染色體異常　出處：《廣東醫(yī)學(xué)》2017年S2期 　論文類型：期刊論文

【摘要】：目的探討孕中期唐氏篩查對檢出胎兒染色體異常的預(yù)測效果。方法對收治的26 841例孕中期(15~20+6周)孕婦進(jìn)行唐氏篩查,并對篩查陽性孕婦進(jìn)行羊水細(xì)胞染色體分析核型診斷,整合資料進(jìn)行統(tǒng)計(jì)分析與數(shù)據(jù)挖掘。結(jié)果參與唐氏篩查的26 841例孕婦中,篩查陽性率隨著年齡的遞增而升高(趨勢X~2=612.53,P0.001),≥35歲陽性率最高,有1 306例,占26.90%;680例參與核型診斷的孕婦中,檢出染色體異常者40例,其中唐氏患兒15例,35歲人群孕唐氏兒11例,占73.33%,≥35歲人群孕唐氏兒4例,占26.67%,差異無統(tǒng)計(jì)學(xué)意義(X~2=0.16,P=0.690.05)。唐氏篩查對其它染色體異常也有提示作用,經(jīng)logistic回歸分析,年齡和lghCG_MoM是患唐氏綜合征的危險(xiǎn)因素,lg AFP_MoM和LgμE3_MoM是保護(hù)因素。不同地域唐氏篩查中位數(shù)參數(shù)不同。結(jié)論各年齡組孕婦均應(yīng)重視唐氏綜合征的篩查與預(yù)防,我國目前應(yīng)堅(jiān)持以血清學(xué)篩查為基礎(chǔ),以無創(chuàng)DNA檢測為補(bǔ)充的篩查策略,各地區(qū)應(yīng)建立自己的中位數(shù)系統(tǒng)以保證和提升篩查的效率。
[Abstract]:Objective to investigate the predictive effect of Down's screening in the second trimester of pregnancy for the detection of fetal chromosomal abnormalities. Methods 26 841 pregnant women with fetal chromosomal abnormalities were screened during the second trimester of pregnancy, and the karyotypes of amniotic fluid were diagnosed by chromosome analysis of amniotic fluid in 26 841 pregnant women. Results among 26 841 pregnant women who participated in Down's screening, the positive rate of screening increased with the increase of age. Of 680 pregnant women who participated in karyotype diagnosis, 40 cases were detected chromosomal abnormalities. Among them, 15 cases of Down's children were pregnant with the age of 35 years, 11 cases (73.33%) were pregnant, and 4 cases were pregnant women of 鈮，

本文編號：1608086