發(fā)布時間：2018-03-13 05:05

  本文選題：硫胺素代謝異常　切入點：胎兒生長發(fā)育　出處：《上海交通大學》2014年碩士論文　論文類型：學位論文

【摘要】：目的：硫胺素（維生素B1）作為人體內一種重要的輔酶，參與體內糖、蛋白質和脂肪等多種基本物質的代謝過程。硫胺素代謝異常與臨床多種疾病相關，最為熟知的是韋尼克腦病。而胎兒期作為人體生長發(fā)育最為迅速、也可謂最為關鍵的時期，消耗著大量的物質和能量。亞臨床硫胺素代謝異常的孕婦，其新生兒可表現(xiàn)出明顯的神經和循環(huán)系統(tǒng)臨床癥狀，且發(fā)病迅速，導致不良愈后。本文通過查閱國內外文獻，，重點歸納總結了妊娠期及哺乳期硫胺素在體內代謝的變化，及硫胺素代謝異常對胎兒神經系統(tǒng)、心臟及骨骼肌發(fā)育的影響及愈后。 結論：在孕期，體內硫胺素的含量將會發(fā)生不同程度的降低，如不注意補充則很容易轉變?yōu)樯饬x上的硫胺素缺乏，尤其是妊娠劇吐孕婦及妊娠期伴有糖尿病的孕婦。硫胺素代謝異常對發(fā)育中的心臟及神經系統(tǒng)會造成物質和能量代謝異常，從而導致細胞的壞死，正常器官結構的破壞，出現(xiàn)明顯的臨床癥狀。即使是沒有任何臨床表現(xiàn)的硫胺素缺乏的孕婦，其子代胎兒宮內發(fā)育遲緩、出生后發(fā)生心力衰竭、精神運動異常和先天性缺陷的發(fā)生率明顯升高。充足的硫胺素補充治療將可以迅速改善臨床癥狀，并恢復正常的臟器結構。但是，孕期硫胺素的補充劑量至今并沒有共識，需進一步臨床研究。
[Abstract]:Objective: as an important coenzyme in human body, thiamine (vitamin B1) is involved in the metabolism of many basic substances, such as sugar, protein and fat. The abnormal metabolism of thiamine is related to many clinical diseases. Wernicke's encephalopathy is best known. The fetus is the fastest and most critical period of human growth, consuming a great deal of material and energy. The newborns can show obvious clinical symptoms of nerve and circulatory system, and the incidence is rapid, which leads to the bad recovery. This article summarizes the changes of thiamine metabolism in vivo during pregnancy and lactation by consulting domestic and foreign literature. Effects of abnormal metabolism of thiamine on the development of fetal nervous system, heart and skeletal muscle. Conclusion: during pregnancy, the content of thiamine in the body will be decreased in varying degrees, and if not supplemented, it will easily turn into a deficiency of thiamine in the biochemical sense. Especially pregnant women with hyperemesis and gestational diabetes mellitus. Abnormal thiamine metabolism can cause abnormal metabolism of substance and energy in the developing heart and nervous system, resulting in necrosis of cells and destruction of normal organ structure. Develop obvious clinical symptoms. Even in pregnant women with no clinical signs of thiamine deficiency, their offspring have intrauterine growth retardation and postnatal heart failure. The incidence of psychomotor disorders and congenital defects is significantly increased. Adequate thiamine supplementation therapy can quickly improve clinical symptoms and restore normal organ structure. However, there is no consensus on the supplemental dose of thiamine during pregnancy. Further clinical research is needed.
【學位授予單位】：上海交通大學
【學位級別】：碩士
【學位授予年份】：2014
【分類號】：R714.5

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