本文選題：硫胺素代謝異常　切入點(diǎn)：胎兒生長(zhǎng)發(fā)育　出處：《上海交通大學(xué)》2014年碩士論文　論文類(lèi)型：學(xué)位論文

【摘要】：目的：硫胺素（維生素B1）作為人體內(nèi)一種重要的輔酶，參與體內(nèi)糖、蛋白質(zhì)和脂肪等多種基本物質(zhì)的代謝過(guò)程。硫胺素代謝異常與臨床多種疾病相關(guān)，最為熟知的是韋尼克腦病。而胎兒期作為人體生長(zhǎng)發(fā)育最為迅速、也可謂最為關(guān)鍵的時(shí)期，消耗著大量的物質(zhì)和能量。亞臨床硫胺素代謝異常的孕婦，其新生兒可表現(xiàn)出明顯的神經(jīng)和循環(huán)系統(tǒng)臨床癥狀，且發(fā)病迅速，導(dǎo)致不良愈后。本文通過(guò)查閱國(guó)內(nèi)外文獻(xiàn)，，重點(diǎn)歸納總結(jié)了妊娠期及哺乳期硫胺素在體內(nèi)代謝的變化，及硫胺素代謝異常對(duì)胎兒神經(jīng)系統(tǒng)、心臟及骨骼肌發(fā)育的影響及愈后。 結(jié)論：在孕期，體內(nèi)硫胺素的含量將會(huì)發(fā)生不同程度的降低，如不注意補(bǔ)充則很容易轉(zhuǎn)變?yōu)樯饬x上的硫胺素缺乏，尤其是妊娠劇吐孕婦及妊娠期伴有糖尿病的孕婦。硫胺素代謝異常對(duì)發(fā)育中的心臟及神經(jīng)系統(tǒng)會(huì)造成物質(zhì)和能量代謝異常，從而導(dǎo)致細(xì)胞的壞死，正常器官結(jié)構(gòu)的破壞，出現(xiàn)明顯的臨床癥狀。即使是沒(méi)有任何臨床表現(xiàn)的硫胺素缺乏的孕婦，其子代胎兒宮內(nèi)發(fā)育遲緩、出生后發(fā)生心力衰竭、精神運(yùn)動(dòng)異常和先天性缺陷的發(fā)生率明顯升高。充足的硫胺素補(bǔ)充治療將可以迅速改善臨床癥狀，并恢復(fù)正常的臟器結(jié)構(gòu)。但是，孕期硫胺素的補(bǔ)充劑量至今并沒(méi)有共識(shí)，需進(jìn)一步臨床研究。
[Abstract]:Objective: as an important coenzyme in human body, thiamine (vitamin B1) is involved in the metabolism of many basic substances, such as sugar, protein and fat. The abnormal metabolism of thiamine is related to many clinical diseases. Wernicke's encephalopathy is best known. The fetus is the fastest and most critical period of human growth, consuming a great deal of material and energy. The newborns can show obvious clinical symptoms of nerve and circulatory system, and the incidence is rapid, which leads to the bad recovery. This article summarizes the changes of thiamine metabolism in vivo during pregnancy and lactation by consulting domestic and foreign literature. Effects of abnormal metabolism of thiamine on the development of fetal nervous system, heart and skeletal muscle. Conclusion: during pregnancy, the content of thiamine in the body will be decreased in varying degrees, and if not supplemented, it will easily turn into a deficiency of thiamine in the biochemical sense. Especially pregnant women with hyperemesis and gestational diabetes mellitus. Abnormal thiamine metabolism can cause abnormal metabolism of substance and energy in the developing heart and nervous system, resulting in necrosis of cells and destruction of normal organ structure. Develop obvious clinical symptoms. Even in pregnant women with no clinical signs of thiamine deficiency, their offspring have intrauterine growth retardation and postnatal heart failure. The incidence of psychomotor disorders and congenital defects is significantly increased. Adequate thiamine supplementation therapy can quickly improve clinical symptoms and restore normal organ structure. However, there is no consensus on the supplemental dose of thiamine during pregnancy. Further clinical research is needed.
【學(xué)位授予單位】：上海交通大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2014
【分類(lèi)號(hào)】：R714.5

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本文編號(hào)：1604913