本文選題：FOXC2　切入點：宮頸癌　出處：《吉林大學》2014年碩士論文　論文類型：學位論文

【摘要】：全世界每年大約有50萬宮頸癌新發(fā)病例，成為女性生殖系統(tǒng)最常見的三大惡性腫瘤之一。宮頸癌的治愈率低，5年存活率僅為3.2%～13.0%[1]。每年大約有25萬婦女死于宮頸癌，占腫瘤總死亡病例的8%［2］。雖然廣泛開展的宮頸癌普查工作已有效降低了其病死率，但近20年來，宮頸癌發(fā)病率在逐年增高，且呈年輕化趨勢，國內外已均有青春期少女患宮頸癌的病例報道。人乳頭狀瘤病毒（HPV)感染作為宮頸癌發(fā)生的主要病因已被大多數人所知（以16、18型最常見），但HPV感染的患者中僅有一小部分最終發(fā)展成浸潤性宮頸癌，我們推測可能存在其他因素促進宮頸癌發(fā)生發(fā)展。宮頸癌的轉移途徑主要為直接蔓延和淋巴結轉移，且早期即可發(fā)生淋巴結轉移，癌細胞經宮旁轉移至盆腔各組淋巴結再至腹主動脈旁淋巴結，最終至全身性轉移。由于宮頸癌早期常無明顯臨床癥狀、現(xiàn)有的篩查方法檢出率尚不穩(wěn)定，所以明確宮頸癌的發(fā)生、發(fā)展、侵襲、轉移的分子生物學基礎，找到特異性強、靈敏度高的腫瘤標記物，對宮頸癌的早期診斷、早期治療和判斷預后具有重要價值。 人叉頭框-C2（Forkhead Box C2，F(xiàn)OXC2）是一種人胚胎蛋白，有證據顯示它在胚胎心血管、淋巴管、軟骨組織、骨骼、腎臟、主動脈弓及眼睛間質等許多部位表達。胚胎和腫瘤組織在細胞向遠處遷移等某些生物學行為上，表現(xiàn)出極大的相似性。近年來亦有研究表明，，F(xiàn)OXC2參與了乳腺癌、淋巴瘤、子宮腺肌癥及婦科惡性腫瘤的侵襲和轉移，但報道FOXC2蛋白在宮頸癌中的檢測相對較少，值得進一步研究。本實驗收集了2010年1月-2013年4月于吉林大學第一醫(yī)院接受手術治療的正常宮頸組織21例，CIN組織30例（其中CINI-II組11例、CINIII組19例），宮頸癌組織58例。應用免疫組化方法檢測FOXC2在正常宮頸組織、宮頸上皮內瘤變（cervical intraepithelial neoplasia，CIN）和宮頸癌組織中的表達情況，研究FOXC2在宮頸癌發(fā)生、發(fā)展、侵襲和轉移中的作用，分析FOXC2與宮頸癌各臨床病理特征之間的關系，如臨床期別、分化程度、有無淋巴結轉移、年齡及腫物大小等。探討FOXC2在宮頸癌的早期診斷、監(jiān)測復發(fā)和判斷預后中的臨床意義。
[Abstract]:There are about 500 thousand new cases of cervical cancer each year in the world, has become one of the three most common malignant tumor of the female reproductive system of cervical cancer. The cure rate is low, the 5 year survival rate is only 3.2% ~ 13.0%[1]. every year there are about 250 thousand women died of cervical cancer, total cancer deaths accounted for 8% of 2. Although the screening of cervical the work has been carried out a wide range of cancer can reduce the mortality rate, but in the past 20 years, the incidence of cervical cancer increased year by year, and the trend was younger, both at home and abroad have reported cases of adolescent girls suffering from cervical cancer. Human papillomavirus (HPV) infection as the main cause of cervical cancer has been most people know (the most common type of 16,18), but HPV infection in patients with only a small part of eventually develop into invasive cervical cancer, we speculate that there may be other factors to promote the development of cervical cancer. Cervical cancer is the main way to transfer straight The spread of metastasis and lymph nodes, and occurs in the early stage of lymph node metastasis, cancer cells by parametrial lymph node metastasis to the pelvic and paraaortic lymph nodes, ultimately to systemic metastasis. As a result of early cervical cancer have no obvious clinical symptoms, screening methods of existing detection rate is not stable, so clear of cervical cancer the occurrence, development, invasion and metastasis, molecular biology, found strong specificity and high sensitivity of tumor markers in the early diagnosis of cervical cancer, has important value for early treatment and prognosis.
Forkhead box -C2 (Forkhead Box C2, FOXC2) is a human embryo protein, there is evidence of it in embryonic heart, lymphatic vessels, cartilage, bone, kidney, the expression of aortic arch and interstitial eyes and many other parts. The embryo and the tumor tissue to the distant migration of some biological behavior in cells. Show great similarity. Recently, studies have shown that FOXC2 is involved in breast cancer, lymphoma, adenomyosis and gynecological malignant tumor invasion and metastasis, but reported the detection of FOXC2 protein in cervical cancer is relatively small, it is worth further research. The normal cervical tissue were collected during January 2010 -2013 April in No.1 Hospital of Jilin University surgical treatment of 21 cases, 30 cases of CIN tissues (including 11 cases of CINI-II group, CINIII group, 19 cases), 58 cases of cervical carcinoma. Immunohistochemical method was used to detect FOXC2 in normal cervical tissues, cervical intraepithelial neoplasia ( Cervical intraepithelial neoplasia, CIN) expression and cervical carcinoma, FOXC2 in cervical cancer occurrence, development, invasion and metastasis, to analyze the relationship between FOXC2 and cervical cancer clinical pathological features, such as clinical stage, degree of differentiation, lymph node metastasis, age and tumor size. Study of FOXC2 in the early diagnosis of cervical cancer and the clinical significance of monitoring the recurrence and prognosis.

【學位授予單位】：吉林大學
【學位級別】：碩士
【學位授予年份】：2014
【分類號】：R737.33

【參考文獻】

中國期刊全文數據庫 前10條

1 張松靈;張立紅;鐘艷平;李玉林;;人宮頸癌組織中CK17和P63蛋白的表達及意義[J];吉林大學學報(醫(yī)學版);2009年05期

2 袁媛;孫偉莉;李衛(wèi)鵬;;腫瘤標志物在宮頸癌的診治及預后中的價值(文獻綜述)[J];放射免疫學雜志;2009年03期

3 Mei-ying Weng;Lin Li;Shu-ying Feng;Shun-jia Hong;;Expression of Bmi-1,P16,and CD44v6 in Uterine Cervical Carcinoma and Its Clinical Significance[J];Cancer Biology & Medicine;2012年01期

4 熊德明;張瑤;王國平;李剛;徐曉剛;冉文華;劉學芬;;FOXC2和Vimentin蛋白在胃癌中的表達及意義[J];重慶醫(yī)學;2013年30期

5 周新華;宋磊;;聯(lián)合檢測血清CA125和CA199在宮頸腺癌患者中診斷價值[J];中華實用診斷與治療雜志;2011年07期

6 趙蕊,朱元莉,周羨梅,葉嗣懋,白若昀,耿力;子宮頸儲備細胞增生與CD44v5在其細胞中的表達[J];解剖學報;2004年05期

7 黃之文;羅海華;;血清鱗狀細胞癌抗原在監(jiān)測宮頸鱗癌患者復發(fā)中的意義[J];檢驗醫(yī)學與臨床;2012年22期

8 黃平;黃慧;李蓉;陳光元;敬宗玉;謝家濱;;Oct4在宮頸癌中的表達及與人乳頭瘤病毒感染的關系[J];檢驗醫(yī)學與臨床;2013年20期

9 楊葉青;梁衛(wèi)江;羅榮城;陳曉華;阮健;;血清SCCA、CYFRA21-1、TPS在宮頸鱗癌的表達及對化療療效評價的意義[J];熱帶醫(yī)學雜志;2011年05期

10 劉珉,劉偉;FOXC2的研究進展[J];上海第二醫(yī)科大學學報;2005年07期

中國博士學位論文全文數據庫 前2條

1 范艷艷;叉頭框C2與子宮內膜癌發(fā)生及淋巴轉移的相關性研究[D];吉林大學;2010年

2 張海軍;Oct-4的表達與宮頸癌生物學行為的關系[D];吉林大學;2013年

本文編號：1591232