本文選題：凝溶膠蛋白　切入點(diǎn)：維生素D結(jié)合蛋白　出處：《中國醫(yī)科大學(xué)學(xué)報》2015年10期 　論文類型：期刊論文

【摘要】：目的探討子癇前期患者外周血中凝溶膠蛋白(GSN)、游離維生素D結(jié)合蛋白(VDBP)及凝血—纖溶指標(biāo)的變化與子癇前期發(fā)生發(fā)展的關(guān)系。方法選取子癇前期重度(SPE)、輕度(MPE)患者各30例、同孕齡健康孕婦(對照組1)和足月健康孕婦(對照組2)各30例,比較4組外周血中血漿GSN和游離VDBP的水平,以及凝血指標(biāo)血小板(PLT)、凝血酶原時間(PT)、活化的部分凝血活酶時間(APTT)、凝血酶時間(TT)、纖維蛋白原(FIB)、D-二聚體(D-dimer)的水平。結(jié)果 MPE和SPE組中GSN、VDBP及PLT、PT、APTT、FIB的含量均明顯低于對照組1(P0.05),D-dimer明顯高于對照組1(P0.05)。SPE組中GSN、VDBP及PLT、PT、APTT、FIB的含量明顯低于MPE組(P0.05),D-dimer明顯高于MPE組(P0.05)。在健康孕婦中,對照組1與對照組2相比,隨著孕周的增加,GSN水平呈下降趨勢,VDBP水平呈上升趨勢,均無統(tǒng)計學(xué)差異(P0.05),同時凝血指標(biāo)均無統(tǒng)計學(xué)差異(P0.05)。結(jié)論子癇前期患者外周血中GSN、VDBP水平較健康孕婦顯著降低,血液呈病理性高凝狀態(tài),且隨著病情加重變化更為明顯,與孕周關(guān)系不大。
[Abstract]:Objective to investigate the relationship between the changes of GSNN, VDBP and coagulation / fibrinolysis in peripheral blood of preeclampsia patients and the development of preeclampsia. Methods 30 patients with severe preeclampsia and 30 patients with mild preeclampsia were selected. The levels of plasma GSN and free VDBP in peripheral blood were compared in 30 healthy pregnant women of the same gestational age (control group 1) and 30 full-term healthy pregnant women (control group 2). The levels of thromboplastin, prothrombin time (PTT), activated partial thromboplastin time (APTTT), thrombin time (TTT), fibrinogen FIBB D- dimer (D-dimer) in MPE and SPE groups were significantly lower than those in control group. The levels of GSNV DBP and PLT PPTT APTTTIB in group 1 were significantly higher than those in group 1 (P 0 05), and the levels of D-dimer in group 1 (P 0. 05) were significantly higher than those in group 1 (P 0. 05). In healthy pregnant women, the levels of GSNN VDBP and PLTX PTT were significantly lower than those of MPE group (P 0. 05). Compared with control group 2, the level of GSN in control group 1 decreased and VDBP increased with the increase of gestational age. There was no significant difference in blood coagulation parameters (P 0.05). Conclusion the level of GSN-VDBP in peripheral blood of preeclampsia patients was significantly lower than that of healthy pregnant women, and the blood was in a pathological hypercoagulable state, and the changes were more obvious with the exacerbation of the disease. It has little to do with gestational age.
【作者單位】： 中國醫(yī)科大學(xué)附屬盛京醫(yī)院婦產(chǎn)科;
【分類號】：R714.245

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