本文選題：乳腺癌　切入點(diǎn)：子宮內(nèi)膜癌　出處：《首都醫(yī)科大學(xué)學(xué)報(bào)》2017年01期 　論文類型：期刊論文

【摘要】：目的 探討乳腺癌術(shù)后并發(fā)婦科惡性腫瘤病人的高危因素。方法 對(duì)首都醫(yī)科大學(xué)附屬北京朝陽(yáng)醫(yī)院收治的乳腺癌術(shù)后并發(fā)婦科惡性腫瘤病人進(jìn)行隨訪,按照病例組∶對(duì)照組=1∶4的比例選取未并發(fā)婦科惡性腫瘤的乳腺癌病人作為對(duì)照組,收集病人乳腺癌相關(guān)資料、月經(jīng)生育相關(guān)資料、腫瘤家族史等資料,采用SPSS18.0統(tǒng)計(jì)軟件進(jìn)行數(shù)據(jù)統(tǒng)計(jì),單因素分析采用χ2檢驗(yàn),多因素分析采用非條件Logistic回歸。結(jié)果 乳腺癌并發(fā)的婦科惡性腫瘤包括子宮內(nèi)膜癌及卵巢癌。單因素分析顯示,初潮年齡(OR=6.5,95%CI:2.37~27.81)、一級(jí)親屬腫瘤家族史(OR=3.57,95%CI:1.27~10.06)、乳腺或婦科惡性腫瘤家族史(OR=5.13,95%CI:1.47~17.92)、合并糖尿病(OR=2.12,95%CI:1.32~12.70)是乳腺癌并發(fā)婦科惡性腫瘤的高危因素。術(shù)后內(nèi)分泌治療(OR=0.29,95%CI:0.11~0.78)、術(shù)后定期婦科檢查(OR=0.33,95%CI:0.12~0.86)降低乳腺癌并發(fā)婦科惡性腫瘤的危險(xiǎn)。多因素分析顯示,乳腺或婦科惡性腫瘤家族史(P=0.003,OR=5.951)、初潮年齡早(P=0.000,OR=9.909)、患有糖尿病(P=0.010,OR=9.842)是乳腺癌并發(fā)婦科惡性腫瘤的高危因素,乳腺癌術(shù)后定期婦科檢查(P=0.037,OR=0.268)是其保護(hù)性因素。結(jié)論腫瘤家族史尤其是乳腺或婦科惡性腫瘤家族史、初潮年齡早、合并糖尿病是乳腺癌術(shù)后發(fā)生婦科惡性腫瘤的高危因素,術(shù)后定期婦科檢查是避免并發(fā)婦科惡性腫瘤的保護(hù)性因素。
[Abstract]:Objective to investigate the high risk factors of breast cancer complicated with gynecologic malignant tumor after operation. Methods follow up the patients with gynecologic malignancy after breast cancer operation in Beijing Chaoyang Hospital affiliated to Capital Medical University. According to the case group: control group 1: 4 selected breast cancer patients without gynecologic malignancy as control group, collected data related to breast cancer, menstrual birth related data, family history of tumor, etc. SPSS18.0 statistical software was used to analyze the data, 蠂 2 test was used for univariate analysis and non-conditional Logistic regression was used for multivariate analysis. Results the gynecologic malignant tumors complicated by breast cancer, including endometrial carcinoma and ovarian cancer, were analyzed by univariate analysis. The age of menarche is 6.5% 2.37% 27.81%, the family history of first-degree relatives' tumor is 3.5795 CI: 1.2710.06, the family history of breast or gynecological malignant tumor is OR5.13 ~ 95CI: 17.92, and the diabetes mellitus OR2.1295CI1.3212.70) is the high risk factor of breast cancer complicated with gynecologic malignancy. The postoperative endocrine therapy OR0.2995CIT 0.110.78, and the regular gynecological examination after operation, OR0.33C95CI0.12o 0.86) decrease the risk factor of breast cancer complicated with gynecologic malignancy (OR2.1295CI1.321.3212.70). Low risk of breast cancer complicated with gynecologic malignancy. Multivariate analysis showed that, The family history of breast or gynecological malignancy (P0. 003) was 5.951, and the age of menarche was 0. 000, OR9. 909, with diabetes mellitus (P0. 010) and OR9. 842) was a high risk factor for breast cancer complicated with gynecologic malignancy. Conclusion the family history of breast cancer, especially the family history of breast cancer or gynecological malignant tumor, early menarche age and diabetes mellitus are the high risk factors for the occurrence of gynecologic malignant tumor after breast cancer operation. Regular gynecologic examination after operation is a protective factor to avoid complicated gynecologic malignant tumor.
【作者單位】： 首都醫(yī)科大學(xué)附屬北京朝陽(yáng)醫(yī)院婦產(chǎn)科;首都醫(yī)科大學(xué)附屬北京朝陽(yáng)醫(yī)院乳腺外科;
【分類號(hào)】：R73

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