本文關(guān)鍵詞： 子宮內(nèi)膜癌 TC-GA 核酸外切酶 錯(cuò)配修復(fù)蛋白 組織形態(tài)學(xué) 組織分型 分子分型 免疫組化法 基因拷貝數(shù) 突變型　出處：《臨床與實(shí)驗(yàn)病理學(xué)雜志》2017年09期 　論文類型：期刊論文

【摘要】：正子宮內(nèi)膜癌可依據(jù)其組織形態(tài)學(xué)進(jìn)行分類,但如果形態(tài)學(xué)多樣化或模棱兩可時(shí)可能影響組織分型診斷。近期有報(bào)道子宮內(nèi)膜癌有兩種分子分型方法:(1)應(yīng)用癌癥基因組圖譜(TCGA)依據(jù)基因組整合分析、轉(zhuǎn)錄、蛋白組學(xué)、基因拷貝數(shù)及甲基化值等將子宮內(nèi)膜癌分為4型:(1)POLE突變型;(2)微衛(wèi)星不穩(wěn)定型;(3)基因低拷貝型;(4)基因高拷貝型。(2)通過測序檢測POLE核酸外切酶區(qū)域是否突變和免疫組化法檢測p53和錯(cuò)配修復(fù)蛋白(MMR)狀態(tài),從而將其分為4種類型:(1)POLE核酸外切酶突變型(POLE EDM),(2)錯(cuò)配修
[Abstract]:Endometrial carcinoma can be classified according to its histomorphology. However, if morphologic diversity or ambiguity may affect the diagnosis of tissue typing, it has recently been reported that there are two molecular typing methods for endometrial carcinoma: 1) the cancer genome map (TCGA) is based on genome integration analysis, transcription, and proteomics. Endometrial carcinoma was classified into 4 types: 1 / 1 POLE mutagenesis, 2) microsatellite instability, 1) low copy gene, low copy gene, high copy type. 2) sequencing to detect whether the exonuclease region of POLE nucleic acid was mutated and immunized. P53 and mismatch repair protein MMRs were detected by chemical method. Thus it can be divided into four types: 1 / 1 of POLE nucleic acid exonuclease mutagenesis type of POLE EDMN / 2) mismatch modification.
【作者單位】： 南京軍區(qū)福州總醫(yī)院病理科;
【分類號】：R737.33

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