本文關(guān)鍵詞： 人工胎盤 胎羊 心功能 心輸出量 Tei指數(shù)　出處：《中國(guó)體外循環(huán)雜志》2014年01期 　論文類型：期刊論文

【摘要】：目的運(yùn)用超聲技術(shù)探討靜脈到靜脈人工胎盤對(duì)胎羊心功能的影響。方法孕100~140 d的山羊5只,切開子宮,建立靜脈到靜脈的人工胎盤轉(zhuǎn)流方式。血液從右頸內(nèi)靜脈引出,經(jīng)過人工胎盤后從臍靜脈回輸?shù)教パ蝮w內(nèi)。胎羊脫離母體后放置在40℃生理鹽水中。人工胎盤裝置包括離心泵、新生兒膜式氧合器、小兒超濾器等。分別于轉(zhuǎn)流前、轉(zhuǎn)流3 h、6 h和9 h對(duì)胎羊心功能進(jìn)行超聲評(píng)估,計(jì)算左、右心室的心排出量和Tei指數(shù)。采血監(jiān)測(cè)血?dú)�、血漿肌鈣蛋白的變化。結(jié)果胎羊體重0.9~2.0(1.66±0.47)kg,胎齡100~140(128±16)d,轉(zhuǎn)流時(shí)間11~14.5(13.1±1.47)h。轉(zhuǎn)流期間,灌注流量恒定,胎羊血壓、心率沒有顯著變化。左心室的心排量和Tei指數(shù)變化沒有統(tǒng)計(jì)學(xué)意義;右心室心排量明顯下降(P0.01);Tei指數(shù)顯著上升(P0.05)。轉(zhuǎn)流過程中血漿肌鈣蛋白含量明顯升高(P0.01)。胎羊均死于心臟停搏。結(jié)論頸內(nèi)靜脈到臍靜脈的人工胎盤技術(shù)可行,但是人工胎盤轉(zhuǎn)流影響胎羊右心功能。
[Abstract]:Objective to study the effect of artificial placenta from vein to vein on the cardiac function of fetal sheep by using ultrasound technique. Methods five goats of 100140 days gestation were cut open uterus and established artificial placental bypass from vein to vein. The blood was drawn from the right internal jugular vein. The artificial placenta device includes centrifugal pump, membrane oxygenator for newborn, ultrafilter for children and so on. Before bypass, the fetal sheep are placed in normal saline at 40 鈩，

本文編號(hào)：1542573