本文關(guān)鍵詞： 妊娠期肝內(nèi)膽汁淤積癥 母嬰結(jié)局　出處：《中國婦產(chǎn)科臨床雜志》2017年05期 　論文類型：期刊論文

【摘要】：目的探討妊娠期肝內(nèi)膽汁淤積癥(intrahepatic cholestasis of pregnancy,ICP)對母嬰結(jié)局的影響。方法收集2011年5月至2016年12月在上海交通大學(xué)醫(yī)學(xué)院附屬蘇州九龍醫(yī)院接受治療的161例ICP患者為研究組,根據(jù)患者的血清總膽汁酸水平將其分為輕度組(116例)與重度組(45例),觀察兩組患者母嬰結(jié)局的差異。結(jié)果重度組總膽汁酸(total bile acid,TBA)谷丙轉(zhuǎn)氨酶(alanine aminotransferase,ALT)以及谷草轉(zhuǎn)氨酶(aspartate aminotransferase,AST)水平顯著高于輕度組,差異有統(tǒng)計學(xué)意義(P0.05),重度組終止妊娠時間和陰道分娩比例顯著低于輕度組,差異有統(tǒng)計學(xué)意義(P0.05),輕度組與重度組的產(chǎn)后出血比列、新生兒體重及Apgar評分無明顯差別,差異均無統(tǒng)計學(xué)意義(P0.05)。結(jié)論妊娠期ICP是導(dǎo)致不良母嬰結(jié)局的一項重要原因,應(yīng)加強對產(chǎn)婦的產(chǎn)前檢查以及圍生期的胎兒監(jiān)護護理。
[Abstract]:Objective to investigate the effect of intrahepatic cholestasis of pregnancy (cholestasis) on maternal and infant outcomes. Methods from May 2011 to December 2016, 161 patients with ICP received treatment in Suzhou Jiulong Hospital, School of Medicine of Shanghai Jiaotong University as study group. According to the serum total bile acid level, the patients were divided into mild group (116 cases) and severe group (45 cases). The difference of maternal and infant outcomes between the two groups was observed. Results Total total bile acid of patients in severe group (total bile acid total bile acidad TBA) alanine aminotransferase (alt) and alanine aminotransferase (alt) were observed. The level of aspartate aminotransferase (AST) was significantly higher in mild group than that in mild group. The time of termination of pregnancy and the proportion of vaginal delivery in severe group were significantly lower than those in mild group (P 0.05). There was no significant difference in postpartum hemorrhage ratio between mild group and severe group. There was no significant difference in neonatal weight and Apgar score between mild group and severe group. Conclusion ICP during pregnancy is an important cause of adverse maternal and infant outcomes. Prenatal examination and perinatal care should be strengthened.
【作者單位】： 上海交通大學(xué)醫(yī)學(xué)院附屬蘇州九龍醫(yī)院婦產(chǎn)科;
【分類號】：R714.255

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