本文關(guān)鍵詞： 孕期不良環(huán)境 代謝綜合征 下丘腦-垂體-腎上腺軸 表觀遺傳修飾 宮內(nèi)編程　出處：《中國(guó)藥理學(xué)與毒理學(xué)雜志》2017年01期 　論文類型：期刊論文

【摘要】：流行病學(xué)調(diào)查提示,孕期不良環(huán)境可引起子代低出生體重及其成年后多種慢性疾病的易感性增加,如代謝性疾病和神經(jīng)精神性疾病等。然而,其發(fā)生機(jī)制尚未見(jiàn)系統(tǒng)的闡明。下丘腦-垂體-腎上腺(HPA)軸是機(jī)體應(yīng)激相關(guān)的重要神經(jīng)內(nèi)分泌軸,在出生前、后的應(yīng)激防御應(yīng)答中發(fā)揮著重要的作用,也是宮內(nèi)時(shí)期胎兒易受損傷的重要靶位。研究發(fā)現(xiàn),孕期多種不良環(huán)境因素(包括外源環(huán)境和母體健康因素)可通過(guò)母體-胎盤-胎兒生物學(xué)單位,多途徑地影響宮內(nèi)胎兒發(fā)育,造成其出生后HPA軸發(fā)育編程改變及成年后多種慢性疾病易感。本綜述結(jié)合本實(shí)驗(yàn)室的最新研究結(jié)果,綜述了國(guó)際上有關(guān)孕期不良環(huán)境所致子代成年疾病易感的病因?qū)W和宮內(nèi)編程機(jī)制的最新進(jìn)展,提出宮內(nèi)母源性糖皮質(zhì)激素過(guò)暴露可引起子代宮內(nèi)神經(jīng)內(nèi)分泌代謝編程改變,其核心是多器官糖皮質(zhì)激素-胰島素樣生長(zhǎng)因子1軸編程,表觀遺傳修飾異常參與其編程過(guò)程。
[Abstract]:Epidemiological studies have shown that adverse conditions during pregnancy can increase the susceptibility of offspring to low birth weight and multiple chronic diseases in adulthood, such as metabolic and neuropsychiatric disorders. The hypothalamus-pituitary-adrenal gland (HPA) axis is an important neuroendocrine axis related to stress, which plays an important role in the stress defense response before and after birth. It is also an important target for fetal vulnerability during intrauterine period. Studies have found that many adverse environmental factors during pregnancy (including exogenous environment and maternal health factors) can be passed through the mother-placenta-fetal biological unit. It affects intrauterine fetal development in many ways, resulting in postnatal HPA axis programming changes and susceptibility to multiple chronic diseases in adulthood. This review combined with the latest research results in our laboratory, This paper reviews the recent advances in the etiology and intrauterine programming mechanism of the susceptibility to adult diseases in offspring due to adverse pregnancy conditions. It is suggested that overexposure of maternal glucocorticoid may cause changes in neuroendocrine and metabolic programming in offspring. Its core is multi-organ glucocorticoid-insulin-like growth factor 1 axis programming, epigenetic modification is involved in its programming process.
【作者單位】： 武漢大學(xué)基礎(chǔ)醫(yī)學(xué)院藥理學(xué)系;發(fā)育源性疾病湖北省重點(diǎn)實(shí)驗(yàn)室;
【基金】：國(guó)家自然科學(xué)基金(30830112);國(guó)家自然科學(xué)基金(81430089);國(guó)家自然科學(xué)基金(81220108026)~~
【分類號(hào)】：R714.2
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本文編號(hào)：1519892