本文關(guān)鍵詞： 宮頸鱗癌 趨化因子受體 細(xì)胞侵襲性　出處：《現(xiàn)代預(yù)防醫(yī)學(xué)》2015年13期 　論文類型：期刊論文

【摘要】：目的檢測(cè)宮頸癌患者鱗癌組織中CXCR4的表達(dá),觀察其與宮頸鱗癌各種臨床病理參數(shù)的關(guān)系,從而為探討CXCR4與宮頸癌侵襲性的機(jī)制研究提供一定的實(shí)驗(yàn)依據(jù)。方法收集我院婦產(chǎn)科收治的145例宮頸癌手術(shù)治療患者臨床病理資料及切除標(biāo)本,采用免疫組織化學(xué)SP法檢測(cè)標(biāo)本中CXCR4的表達(dá)情況,并通過Transwell實(shí)驗(yàn)了解CXCR4過表達(dá)的細(xì)胞遷移情況。結(jié)果不同F(xiàn)IGO病理分期、不同組織分化程度及不同淋巴結(jié)轉(zhuǎn)移情況的患者之間,CXCR4表達(dá)的陽(yáng)性率差異有統(tǒng)計(jì)學(xué)意義(P0.05),FIGO分期為Ⅱ期及Ⅲ期者陽(yáng)性率較高,組織分化程度越低者陽(yáng)性率越高,發(fā)生淋巴結(jié)轉(zhuǎn)移者CXCR4表達(dá)的陽(yáng)性率高于未轉(zhuǎn)移者。宮頸鱗癌細(xì)胞遷移實(shí)驗(yàn)結(jié)果顯示,除CXCR4過表達(dá)3 h和6 h兩個(gè)時(shí)點(diǎn)外,其余各時(shí)間點(diǎn)宮頸鱗癌細(xì)胞過表達(dá)CXCR4組與對(duì)照組相比較,平均遷移細(xì)胞數(shù)的差異均具有統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論宮頸鱗癌組織中CXCR4高表達(dá)可能在宮頸鱗癌的侵襲、轉(zhuǎn)移中起重要作用,對(duì)細(xì)胞侵襲和轉(zhuǎn)移能力有促進(jìn)作用。
[Abstract]:Objective to detect the expression of CXCR4 in squamous cell carcinoma (SCC) of cervical cancer, and to observe the relationship between the expression of CXCR4 and the clinicopathological parameters of cervical squamous cell carcinoma (SCC). Methods the clinical and pathological data and excision specimens of 145 patients with cervical cancer treated by surgical treatment in gynecology and obstetrics department in our hospital were collected. Immunohistochemical SP method was used to detect the expression of CXCR4 in the specimens, and the cell migration of CXCR4 overexpression was studied by Transwell assay. Results the pathological stages of FIGO were different. The positive rate of CXCR4 expression in patients with different tissue differentiation degree and different lymph node metastasis was significantly different. The positive rate of stage 鈪，

本文編號(hào)：1494971