本文關(guān)鍵詞： Ki-67 P16 CK34βE12 宮頸癌 預后　出處：《新疆醫(yī)科大學》2017年碩士論文　論文類型：學位論文

【摘要】：目的:探討Ki-67、P16、CK34βE12蛋白、患者病理特色及術(shù)后輔助診治方式對可手術(shù)的宮頸癌患者的預后價值。辦法:運用免疫組化法檢測72例宮頸癌術(shù)后病理組織中Ki-67、P16、CK34βE12蛋白的表達,聯(lián)合患者病理特色及診治方式,以患者疾病進展為研究終點,隨訪自確診至疾病進展時間(PFS)。單因素分析運用Kaplan-Meier法,多因素分析運用Cox回歸分析。結(jié)果:單因素分析顯示:ki-67(p=0.006)、CK34βE12(p=0.007)、生產(chǎn)次數(shù)(p=0.018)、絕經(jīng)狀況(p=0.008)、民族(p=0.034)、有無疼痛(p=0.008)、腫瘤分期(p=0.000)、腫瘤大小(p=0.015)、淋巴結(jié)轉(zhuǎn)移狀況(p=0.000)、化療狀況(p=0.016)與患者預后相干。Cox分析結(jié)果顯示:宮頸癌患者Ki-67表達狀況、發(fā)病年齡、懷孕次數(shù)、生產(chǎn)次數(shù)、絕經(jīng)狀況、腫瘤分期、是否深肌層受到侵犯、是否沿子宮侵犯、是否放療為影響可手術(shù)宮頸癌患者PFS的顯著性因素(PO.05)。而患者P16和CK34βE12蛋白的表達、腫瘤大小、分化程度、初潮年齡、民族、職業(yè)、手術(shù)和化療狀況等對PFS無顯著影響(PO.05),尚不能作為獨立的預后因素。結(jié)論:ki-67高表達、低齡、早產(chǎn)、腫瘤分期晚,深肌層及沿子宮受侵犯、放射診治均為宮頸癌的獨立預后因素;P16和CK34βE12蛋白的表達、腫瘤大小、分化程度、初潮年齡、民族、職業(yè)、手術(shù)和化療狀況僅與預后相干,尚不能作為獨立的預后因素。
[Abstract]:Objective: to investigate the prognostic value of Ki-67G P16CK34 尾 E12 protein, the pathological features of patients and the way of postoperative diagnosis and treatment. Methods: the expression of Ki-67P16CK34 尾 E12 protein was detected by immunohistochemical method in 72 cases of cervical carcinoma after operation. Combined with the pathological characteristics and diagnosis and treatment of the patients, the end point of the study was the progression of the disease, and the time from the diagnosis to the progression of the disease was followed up. Kaplan-Meier method was used in univariate analysis. Multivariate analysis using Cox regression analysis. Results: univariate analysis showed that:% ki-67 p0. 006, CK34 尾 E12, p0. 007, p0. 018, menopausal status, P0. 008, P0. 034, pain, stage, p0. 0000, size of tumor p0. 015, lymph node metastasis p0. 0000, chemotherapy status p0. 016) and prognosis of patients. The results of correlation. Cox analysis showed that the expression of Ki-67 in patients with cervical cancer, Age of onset, number of pregnancies, number of births, menopause, stage of tumor, invasion of deep muscle layer, invasion of uterus, The expression of P16 and CK34 尾 E12 protein, tumor size, differentiation degree, menarche age, nationality, occupation, etc. Operation and chemotherapy had no significant effect on PFS, and could not be used as an independent prognostic factor. Conclusion: high expression of Ki-67, low age, premature delivery, late tumor stage, invasion of deep muscular layer and uterus along the uterus. Radiotherapy was an independent prognostic factor for cervical cancer. The expression of P16 and CK34 尾 E12 protein, tumor size, differentiation, menarche age, nationality, occupation, operation and chemotherapy were not independent prognostic factors.
【學位授予單位】：新疆醫(yī)科大學
【學位級別】：碩士
【學位授予年份】：2017
【分類號】：R737.33

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