本文關(guān)鍵詞： 早期復(fù)發(fā)性流產(chǎn) 阿司匹林 子宮動(dòng)脈血流 子宮內(nèi)膜血流 子宮內(nèi)膜容受性　出處：《上海交通大學(xué)學(xué)報(bào)(醫(yī)學(xué)版)》2017年04期 　論文類型：期刊論文

【摘要】：目的·研究早期復(fù)發(fā)性流產(chǎn)(ERSA)患者黃體中期子宮血流參數(shù)特征,觀察阿司匹林對(duì)子宮血液動(dòng)力學(xué)的作用。方法·采用經(jīng)陰道彩色多普勒超聲檢測(cè)271例有ERSA史婦女(ERSA組)和66例無反復(fù)自然流產(chǎn)史婦女(對(duì)照組)的黃體中期子宮內(nèi)膜厚度和子宮血流參數(shù)。ERSA組予阿司匹林50 mg/d口服2個(gè)月及個(gè)體化治療,觀察其對(duì)子宮血流參數(shù)及再次妊娠的早期妊娠結(jié)局的影響。結(jié)果·ERSA組黃體中期子宮內(nèi)膜厚度顯著小于對(duì)照組,而內(nèi)膜血流搏動(dòng)指數(shù)(PI)、子宮動(dòng)脈平均PI(m PI)、平均阻力指數(shù)(m RI)和平均收縮期峰值流速/舒張末期流速(m S/D)均顯著高于對(duì)照組(均P0.05)。阿司匹林治療2個(gè)月后,ERSA組子宮血流阻力明顯改善(P=0.000),且對(duì)于子宮內(nèi)膜厚度7 mm的患者,用藥后子宮內(nèi)膜厚度增加,差異有統(tǒng)計(jì)學(xué)意義(P=0.000)。ERSA組中163例完成阿司匹林治療2個(gè)月后的子宮血流參數(shù)復(fù)測(cè),其中136名患者經(jīng)個(gè)體化治療后再次妊娠,其中97名患者妊娠≥12周,10名患者于妊娠12周內(nèi)再次流產(chǎn),29名患者早期妊娠結(jié)局尚無法確定。結(jié)論·ERSA患者黃體中期子宮血流阻力較正常育齡婦女顯著增加,內(nèi)膜厚度較薄。阿司匹林可改善ERSA患者的子宮血流灌注,有利于早期妊娠結(jié)局的改善。
[Abstract]:Objective: to study the characteristics of uterine blood flow parameters in patients with early recurrent abortion (ERSA). To observe the effect of aspirin on uterine hemodynamics. Methods: 271 women with history of ERSA and 66 women with no history of recurrent spontaneous abortion were examined by transvaginal color Doppler ultrasound. ERSA group was given aspirin 50 mg/d orally for 2 months and individualized treatment. Results: the endometrial thickness in ERSA group was significantly lower than that in control group, while the endometrial blood flow pulsatility index (Pi) was significantly lower in the ERSA group than in the control group. Uterine artery mean PI(m Pi). The mean resistance index (mRI) and the mean peak systolic velocity / end-diastolic velocity (MS / D) were significantly higher than those in the control group (P < 0.05). After 2 months of aspirin therapy, the mean resistance index was significantly higher than that in the control group (P < 0.05). The uterine blood flow resistance in ERSA group was significantly improved, and the endometrial thickness increased in patients with endometrial thickness of 7 mm. There were significant differences in uterine blood flow parameters of 163 patients in the Pu 0.000U. ERSA group after 2 months of aspirin therapy. 136 patients were pregnant again after individualized treatment. Among them, 97 patients with pregnancy 鈮，

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