發(fā)布時間：2018-01-19 16:08

  本文關(guān)鍵詞： 子宮內(nèi)膜異位癥 脆性組氨酸三聯(lián)體 免疫組化　出處：《實用醫(yī)學(xué)雜志》2015年16期 　論文類型：期刊論文

【摘要】：目的:觀察脆性組氨酸三聯(lián)體(FHIT)蛋白在子宮內(nèi)膜異位癥(EMT)中的表達及意義。方法:應(yīng)用免疫組化SP法檢測FHIT在28例EMT患者(EMT組)的在位內(nèi)膜、異位內(nèi)膜及28例單純子宮肌瘤患者(對照組)子宮內(nèi)膜中的表達情況。結(jié)果:FHIT主要表達在子宮內(nèi)膜腺體上皮細胞的胞漿和胞膜中。FHIT在EMT患者的在位內(nèi)膜和異位內(nèi)膜的陽性率分別為68%(19/28)和54%(15/28),兩者相比差異無統(tǒng)計學(xué)意義(P0.05);但均低于對照組的96%(27/28),差異有統(tǒng)計學(xué)意義(P0.05);EMT不同re-AFS分期的異位子宮內(nèi)膜中,FHIT的表達情況不同,Ⅰ~Ⅱ期的陽性率較Ⅲ~Ⅳ期的陽性率明顯升高,差異有統(tǒng)計學(xué)意義(P0.05)。結(jié)論 :FHIT可能與EMT的發(fā)病有關(guān),并對疾病的嚴重程度有一定的影響。
[Abstract]:Objective: to observe the expression and significance of fragile histidine triad FHITprotein in endometriosis. Methods: immunohistochemical SP method was used to detect FHIT in 28 patients with EMT. The eutopic intima of EMT group. Ectopic endometrium and 28 patients with simple uterine leiomyoma (control group). Expression in endometrium. Results:. The positive rates of FHIT mainly expressed in cytoplasm and membrane of endometrial glandular epithelial cells were 68% in eutopic endometrium and ectopic endometrium in EMT patients. 19 / 28) and 54 / 15 / 28). There was no significant difference between the two groups (P 0.05). But it was significantly lower than that of the control group (96 / 27 / 28), and the difference was statistically significant (P 0.05). The expression of FHIT in ectopic endometrium with different re-AFS stages of EMT was different. The positive rate of FHIT in stage 鈪，

本文編號：1444885