本文關(guān)鍵詞： 子宮腺肌病 痛經(jīng) PLA2 PGF2a LI-6　出處：《福建醫(yī)科大學(xué)》2014年碩士論文　論文類型：學(xué)位論文

【摘要】：目的:探討子宮腺肌病中痛經(jīng)與炎性介質(zhì)的關(guān)系及相關(guān)臨床特點。方法:選擇福建中醫(yī)藥大學(xué)附屬人民醫(yī)院2011年10月～2012年10月因子宮腺肌病住院擬行腹腔鏡子宮切除的病例100例，所有患者均采用腹腔鏡手術(shù)治療，其中腹腔鏡全子宮切除54例，腹腔鏡次全子宮切除46例，并經(jīng)術(shù)后病理確診。根據(jù)患者術(shù)前痛經(jīng)程度分4組，，無痛經(jīng)組、輕度痛經(jīng)組、中度痛經(jīng)組、重度痛經(jīng)組。以同期無痛經(jīng)癥狀的子宮肌瘤住院行手術(shù)治療病例100例為對照組。分析痛經(jīng)與子宮大小、血清CA125、IL-6，腹腔液測定PGF2a及sPLA2值的關(guān)系。對手術(shù)方式及術(shù)后1-6月恢復(fù)情況進(jìn)行隨訪和回顧分析。 結(jié)果：1、子宮腺肌病組平均年齡較子宮肌瘤組提前6年。 2、血清CA125值在子宮腺肌�。ˋM）組（125.62±20.34U/ml），明顯高于對照組（15.91±11.52U/ml）(P0.05)，并與子宮大小呈正相關(guān)(P0.05)。 白介素6（IL-6）、腹腔液前列腺素（PGF2a）、磷脂酶A2（sPLA2）在AM組（52.23±4.93pg/ml，83.43±5.93ρ/pg mg-1,76.34±5.34u/L,)高于對照組(15.23±6.07pg/ml，33.64±5.95,34ρ/pg mg-1,42±11.32u/L)(P0.05)，與痛經(jīng)程度正相關(guān)(P0.05)。 3、子宮切除手術(shù)均能滿意緩解近期痛經(jīng)癥狀，但次全子宮切除較行全子宮切除更有利于術(shù)后恢復(fù)。 結(jié)論：1.子宮腺肌癥疼痛程度與機體內(nèi)源性炎癥因子IL-6、PLA2、PGF2a有關(guān)。 2．痛經(jīng)是患者行手術(shù)治療的主要原因，子宮切除手術(shù)對緩解近期疼痛癥狀有效。
[Abstract]:Objective: to investigate the relationship between dysmenorrhea and inflammatory mediators in adenomyosis. A total of 100 patients with adenomyosis were selected from the people's Hospital of Fujian University of traditional Chinese Medicine from October 2011 to October 2012. All patients were treated by laparoscopic hysterectomy 54 cases laparoscopic subtotal hysterectomy 46 cases confirmed by postoperative pathology. According to the degree of preoperative dysmenorrhea patients were divided into 4 groups without dysmenorrhea group. Mild dysmenorrhea group, moderate dysmenorrhea group, severe dysmenorrhea group. 100 cases of myoma without dysmenorrhea were treated by operation in the same period as control group. The size of dysmenorrhea and uterus, serum CA125 were analyzed. The relationship between IL-6 and PGF2a and sPLA2 in peritoneal fluid was analyzed retrospectively. The operative method and the recovery from 1 to 6 months after operation were followed up and analyzed retrospectively. Results the average age of adenomyosis group was 6 years earlier than that of hysteromyoma group. 2Serum CA125 level was 125.62 鹵20.34 U / ml in adenomyosis group. It was significantly higher than that in the control group (15.91 鹵11.52 U / ml, P 0.05, P 0.05), and was positively correlated with the size of uterus. Interleukin-6, prostaglandin PGF2a, phospholipase A2sPLA2) was 52.23 鹵4.93 PG / ml in AM group. 83.43 鹵5.93 蟻 / PG mg-1a 76.34 鹵5.34 u / L) was higher than that of the control group (15.23 鹵6.07pg / ml, 33.64 鹵5.95). 34 蟻 / PG mg ~ (-1) 42 鹵11.32 u 路L ~ (-1) P _ (0.05), which was positively correlated with the degree of dysmenorrhea. 3. Hysterectomy can relieve the symptoms of dysmenorrhea, but subtotal hysterectomy is more beneficial to postoperative recovery than total hysterectomy. Conclusion 1. The degree of pain in adenomyosis is related to the endogenous inflammatory factor IL-6, PLA2 and PGF2a. 2. Dysmenorrhea is the main cause of surgical treatment. Hysterectomy is effective in relieving recent pain symptoms.
【學(xué)位授予單位】：福建醫(yī)科大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2014
【分類號】：R711.71

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