本文關(guān)鍵詞： 激素替代治療 絕經(jīng)期婦女 生存質(zhì)量　出處：《中國藥學(xué)雜志》2017年08期 　論文類型：期刊論文

【摘要】：目的評(píng)價(jià)激素替代治療(HRT)對(duì)絕經(jīng)期婦女生存質(zhì)量的影響。方法收集北京婦產(chǎn)醫(yī)院門診就診的絕經(jīng)期婦女202例,分為未行HRT組(1組),首次HRT組(2組),已行HRT組(3組),跟蹤隨訪1年,每3個(gè)月隨訪1次,由專人評(píng)估患者的改良Kupperman評(píng)分(改良KI)、絕經(jīng)期生存質(zhì)量量表(MENQOL)、焦慮自評(píng)量表(SAS)和抑郁自評(píng)量表(SDS),并對(duì)患者進(jìn)行生活方式的指導(dǎo)。結(jié)果三組患者一年后改良KI、MENQOL、SAS的評(píng)分值有顯著改善(P=0.003,0.007,0.014),且改良KI、MENQOL出現(xiàn)顯著性改善的時(shí)間早于SAS;SDS的評(píng)分值雖有改善,但無顯著性變化(P=0.109)。1組患者各量表評(píng)分有顯著改善,但改善程度弱于2、3組。HRT與各量表的評(píng)分值呈負(fù)相關(guān),文化程度與SAS、SDS的評(píng)分值呈正相關(guān)。結(jié)論 HRT能夠改善患者的生存質(zhì)量,且對(duì)軀體癥狀的改善早于精神癥狀。文化程度高的絕經(jīng)期患者更易發(fā)生焦慮和抑郁。傳統(tǒng)中醫(yī)藥、運(yùn)動(dòng)療法和物理康復(fù)可作為輔助治療手段用于不能或不愿接受HRT的患者。
[Abstract]:Objective to evaluate the effect of hormone replacement therapy (HRT) on the quality of life of menopausal women. Methods 202 postmenopausal women in Beijing Obstetrics and Obstetrics Hospital were divided into 2 groups without HRT. The patients in the first HRT group were followed up for 1 year, followed up once every 3 months. The modified Kupperman score (modified Ki) of the patients was evaluated by special person. The menopausal quality of life scale (MENQOLA), Self-Rating anxiety scale (SAS) and Self-Rating Depression scale (SDS) were used to guide the patients' lifestyle. Results Ki was improved in the three groups after one year. The score of MENQOLN SAS was significantly improved, and the time of significant improvement of modified KI MENQOL was earlier than that of SAS. Although the score of SDS was improved, there was no significant change. The scores of each scale were significantly improved, but the degree of improvement was weaker than that of 2. There was a negative correlation between HRT and the score of each scale, and a positive correlation between the education level and the score of SSAS-SDS. Conclusion HRT can improve the quality of life of the patients. The improvement of somatic symptoms is earlier than that of mental symptoms. Menopausal patients with high education level are more likely to develop anxiety and depression. Traditional Chinese medicine. Exercise therapy and physical rehabilitation can be used as adjuvant therapy for patients who are unable or unwilling to accept HRT.
【作者單位】： 首都醫(yī)科大學(xué)附屬北京婦產(chǎn)醫(yī)院科技處;首都醫(yī)科大學(xué)附屬北京婦產(chǎn)醫(yī)院內(nèi)分泌科;首都醫(yī)科大學(xué)衛(wèi)生管理與教育學(xué)院;
【基金】：首都醫(yī)科大學(xué)基礎(chǔ)-臨床科研合作基金資助項(xiàng)目
【分類號(hào)】：R711.75
【正文快照】： 婦女在絕經(jīng)前后由于卵巢功能的衰退,雌激素水平明顯下降,出現(xiàn)以植物神經(jīng)系統(tǒng)功能紊亂為主伴有精神心理癥狀的一組癥候群,包括血管疏縮癥狀、骨質(zhì)疏松癥狀、泌尿生殖道萎縮、自主神經(jīng)失調(diào)和情緒障礙等,從而影響到女性的生存質(zhì)量。隨著生活水平的提高和婦女壽命的延長,絕經(jīng)前后

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