肺炎支原體感染的哮喘患兒血清CD40L、VCAM-1水平變化及其意義
發(fā)布時(shí)間：2019-04-27 02:43
【摘要】：目的探討肺炎支原體(MP)感染的支氣管哮喘患兒血清CD40L與血管細(xì)胞黏附分子-1(VCAM-1)水平的變化及其意義。方法選擇59例支氣管哮喘患兒作為觀察組,入院后行MP-lg M檢測(cè),根據(jù)MP是否陽性分為MP感染并支氣管哮喘組(MP感染哮喘組)30例、單純支氣管哮喘組(單純哮喘組)29例。另選擇同期正常體檢的兒童27例作為對(duì)照組。MP感染哮喘組中根據(jù)MP-Ig M抗體效價(jià)滴度分為低滴度11例、中滴度10例、高滴度9例三個(gè)水平。清晨抽取三組空腹靜脈血4 m L,離心取上清液,采用酶聯(lián)免疫法測(cè)定血清CD40L及VCAM-1水平。分析MP感染哮喘患兒血清CD40L與VCAM-1水平的相關(guān)性。結(jié)果單純哮喘組及MP感染哮喘組血清CD40L、VCAM-1水平均高于對(duì)照組(P均0.05),MP感染哮喘組血清CD40L、VCAM-1水平均高于單純哮喘組(P均0.05)。高滴度及中滴度患兒血清CD40L、VCAM-1水平均高于低滴度患兒(P均0.05)。高滴度及中滴度患兒間血清CD40L與VCAM-1水平差異無統(tǒng)計(jì)學(xué)意義(P0.05)。MP感染哮喘患兒血清CD40L水平與VCAM-1水平呈正相關(guān)(r=0.634,P0.01)。結(jié)論哮喘患兒存在MP感染時(shí),血清CD40L及VCAM-1水平可進(jìn)一步升高,從而加重呼吸道的慢性炎癥過程,進(jìn)而加重支氣管哮喘。
[Abstract]:Objective to investigate the changes and significance of serum CD40L and vascular cell adhesion molecule-1 (VCAM-1) levels in children with mycoplasma pneumoniae (MP) infection. Methods 59 children with bronchial asthma were selected as observation group. MP-lg M was detected after admission. According to whether MP was positive or not, 30 cases were divided into MP infection and bronchial asthma group (MP infection asthma group). Simple bronchial asthma group (simple asthma group) 29 cases. According to the titers of MP-Ig M antibody in MP infected asthma group, 11 cases were low titre, 10 cases were middle titre and 9 cases were high titre, which were divided into three levels: low titre (n = 11), middle titre (n = 10) and high titre (n = 9). Fasting venous blood (4 mL) was taken from three groups in the morning and the supernatant was centrifuged. Serum CD40L and VCAM-1 levels were measured by enzyme linked immunosorbent assay (Elisa). To analyze the correlation between serum CD40L and VCAM-1 levels in children with MP infection. Results the levels of serum CD40L,VCAM-1 in asthma group and MP infection group were higher than those in control group (P0.05). The serum CD40L,VCAM-1 level in asthma group was higher than that in asthma group (P0.05). The levels of serum CD40L,VCAM-1 in high and medium titers were higher than those in low titers (P0.05). There was no significant difference in serum CD40L and VCAM-1 levels between high titers and middle titers (P0.05). There was a positive correlation between serum CD40L levels and VCAM-1 levels in MP infected asthmatic children (r = 0.634, P0.01). Conclusion Serum CD40L and VCAM-1 levels can be further increased in asthmatic children with MP infection, which can aggravate the chronic inflammation process of respiratory tract and further aggravate bronchial asthma.
【作者單位】： 石河子大學(xué)醫(yī)學(xué)院第一附屬醫(yī)院;
【分類號(hào)】：R725.6
本文編號(hào)：2466623
[Abstract]:Objective to investigate the changes and significance of serum CD40L and vascular cell adhesion molecule-1 (VCAM-1) levels in children with mycoplasma pneumoniae (MP) infection. Methods 59 children with bronchial asthma were selected as observation group. MP-lg M was detected after admission. According to whether MP was positive or not, 30 cases were divided into MP infection and bronchial asthma group (MP infection asthma group). Simple bronchial asthma group (simple asthma group) 29 cases. According to the titers of MP-Ig M antibody in MP infected asthma group, 11 cases were low titre, 10 cases were middle titre and 9 cases were high titre, which were divided into three levels: low titre (n = 11), middle titre (n = 10) and high titre (n = 9). Fasting venous blood (4 mL) was taken from three groups in the morning and the supernatant was centrifuged. Serum CD40L and VCAM-1 levels were measured by enzyme linked immunosorbent assay (Elisa). To analyze the correlation between serum CD40L and VCAM-1 levels in children with MP infection. Results the levels of serum CD40L,VCAM-1 in asthma group and MP infection group were higher than those in control group (P0.05). The serum CD40L,VCAM-1 level in asthma group was higher than that in asthma group (P0.05). The levels of serum CD40L,VCAM-1 in high and medium titers were higher than those in low titers (P0.05). There was no significant difference in serum CD40L and VCAM-1 levels between high titers and middle titers (P0.05). There was a positive correlation between serum CD40L levels and VCAM-1 levels in MP infected asthmatic children (r = 0.634, P0.01). Conclusion Serum CD40L and VCAM-1 levels can be further increased in asthmatic children with MP infection, which can aggravate the chronic inflammation process of respiratory tract and further aggravate bronchial asthma.
【作者單位】： 石河子大學(xué)醫(yī)學(xué)院第一附屬醫(yī)院;
【分類號(hào)】：R725.6
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