【摘要】：小兒多發(fā)性抽動(dòng)癥是兒科較常見(jiàn)神經(jīng)精神系統(tǒng)疾病,現(xiàn)代醫(yī)學(xué)對(duì)其發(fā)病原因不明確,西藥治療副作用大、易復(fù)發(fā)。中醫(yī)臨床上本病以肝亢風(fēng)動(dòng),痰火上擾證為多見(jiàn),中醫(yī)藥對(duì)于本病的治療具有療效穩(wěn)定及副作用小等特點(diǎn),有著廣闊的前景。 目的：對(duì)五靈顆粒治療小兒多發(fā)性抽動(dòng)癥(肝亢風(fēng)動(dòng),痰火上擾證)療效和安全性作進(jìn)一步評(píng)價(jià),并初步探討其作用機(jī)制。 方法：臨床研究收集江蘇省中醫(yī)院等6所醫(yī)院門(mén)診病例。600余例診斷為小兒多發(fā)性抽動(dòng)癥(肝亢風(fēng)動(dòng),痰火上擾證),收集相關(guān)臨床資料,根據(jù)隨機(jī)、雙盲等原則,對(duì)其分別予以口服五靈顆粒、泰比利及安慰劑治療。以評(píng)價(jià)五靈顆粒對(duì)于小兒多發(fā)性抽動(dòng)癥的治療效果及其安全性。 結(jié)果：1.治療后五靈顆粒在改善抽動(dòng)癥狀方面療效優(yōu)于安慰劑組有效,總有效率80.20%,有顯著差異。 2.治療后五靈顆粒在改善抽動(dòng)癥狀方面較泰比利未見(jiàn)明顯差異。 3.治療后五靈顆粒對(duì)改善中醫(yī)癥狀較其它兩組作用明顯。 4.本次臨床試驗(yàn)無(wú)不良事件報(bào)告,未觀察到試驗(yàn)藥物對(duì)心肝腎功能血液系統(tǒng)有異常影響報(bào)告。 結(jié)論：五靈顆粒對(duì)于治療小兒多發(fā)性抽動(dòng)癥在改善抽動(dòng)癥狀方面較安慰劑有顯著療效,在改善抽動(dòng)癥狀方面較泰比利未見(jiàn)明顯差異,在改善相關(guān)中醫(yī)癥狀方面較安慰劑和泰比利有明顯優(yōu)勢(shì),并且無(wú)明顯不良反應(yīng)。在治療小兒多發(fā)性抽動(dòng)癥方面具有臨床實(shí)用價(jià)值。
[Abstract]:Pediatric multiple tic syndrome is a common neuropsychiatric disease in pediatrics. The causes of the disease are not clear in modern medicine, and the side effects of western medicine are big and easy to recur. In clinic, this disease is characterized by hyperactivity of the liver and disturbance of phlegm and fire. Chinese medicine has the characteristics of stable curative effect and small side effects, and has a broad prospect. Objective: to evaluate the efficacy and safety of Wuling granule in the treatment of children with multiple tic syndrome (hyperactivity of the liver, phlegm and fire disturbance), and to explore its mechanism. Methods: clinical data were collected from 6 outpatients of 6 hospitals, including Jiangsu traditional Chinese Medicine Hospital. More than 600 cases were diagnosed with multiple tic syndrome (hyperactivity of the liver, phlegm and fire disturbance), and the related clinical data were collected according to the principles of randomness, double blindness and so on. They were treated with oral Wuling granule, tebureb and placebo, respectively. To evaluate the efficacy and safety of Wuling granule in the treatment of children with multiple tic syndrome. Results: 1. After treatment, Wuling granule was more effective than placebo group in improving tic symptoms, the total effective rate was 80.20 and there was significant difference. 2. After treatment, Wuling granule had no significant difference in improving tic symptoms as compared with that of terbureb. 3. The effect of Wuling granule on improving TCM symptoms was more obvious than that of the other two groups. 4. No adverse events were reported in the clinical trial, and no abnormal effects of the drugs on the heart, liver and kidney function and blood system were observed. Conclusion: Wuling granule is more effective than placebo in the treatment of children with multiple tic syndrome, but there is no significant difference in improving tic symptoms. There were significant advantages over placebo and terburide in improving the symptoms of traditional Chinese medicine, and there were no significant adverse reactions. In the treatment of children with multiple tic disorder has clinical practical value.
【學(xué)位授予單位】：南京中醫(yī)藥大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2012
【分類(lèi)號(hào)】：R272

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