【摘要】：目的探討中國新生兒先天性心臟病(CHD)的主要危險因素,為CHD的預防提供參考依據。方法系統(tǒng)搜集2001~2016年研究中國新生兒CHD危險因素的病例對照研究,提取相關數據,按照NOS量表對納入文獻進行質量評價,敏感性分析采用不同模型分析同一資料,采用Egger's檢驗評估發(fā)表偏倚。結果共納入17篇病例對照研究,其中病例組2 930例,對照組4 952例。Meta分析顯示中國新生兒CHD主要危險因素為:孕母高齡(OR=2.649,95%CI:1.675~4.189)、感冒或發(fā)燒(OR=4.558,95%CI:2.901~7.162)、孕早期用藥(OR=3.961,95%CI:2.816~5.573)、被動吸煙(OR=2.766,95%CI:1.982~3.859)、不良生育史(OR=2.992,95%CI:1.529~5.856)、接觸噪聲(OR=3.030,95%CI:1.476~6.217)、受到輻射(OR=2.363,95%CI:1.212~4.607)、居室新裝修(OR=4.979,95%CI:3.240~7.653)、孕期糖尿病(OR=5.090,95%CI:3.132~8.274)、飼養(yǎng)寵物(OR=2.048,95%CI:1.385~3.029)。結論孕母高齡、感冒或發(fā)燒、孕早期用藥、被動吸煙、不良生育史、接觸噪聲、受到輻射、居室新裝修、孕期糖尿病、飼養(yǎng)寵物可能增加新生兒CHD的患病風險。
[Abstract]:Objective to explore the main risk factors of neonatal congenital heart disease (CHD) in China and to provide reference for the prevention of CHD. Methods A case-control study was conducted to study the risk factors of neonatal CHD in China from 2001 to 2016, and the relevant data were extracted. The quality of the literature was evaluated according to the NOS scale. The sensitivity analysis used different models to analyze the same data. Publication bias was evaluated by Egger's test. Results A total of 17 case-control studies were conducted, including 2 930 cases in the case group and 4 952 cases in the control group. Meta analysis showed that the main risk factors of neonatal CHD in China were: OR=2.649,95%CI:1.675~4.189. Cold or fever (OR=4.558,95%CI:2.901~7.162), early pregnancy medication (OR=3.961,95%CI:2.816~5.573), passive smoking (OR=2.766,95%CI:1.982~3.859), bad birth history (OR=2.992,95%CI:1.529~5.856), Exposure noise (OR=3.030,95%CI:1.476~6.217), exposure to radiation (OR=2.363,95%CI:1.212~4.607), room renovation (OR=4.979,95%CI:3.240~7.653), gestational diabetes mellitus (OR=5.090,95%CI:3.132~8.274), Keep pets (OR=2.048,95%CI:1.385~3.029). Conclusion elderly pregnant mothers, cold or fever, drug use in early pregnancy, passive smoking, bad birth history, exposure to noise, exposure to radiation, newly decorated rooms, diabetes during pregnancy, keeping pets may increase the risk of neonatal CHD.
【作者單位】： 徐州醫(yī)科大學公共衛(wèi)生學院;新鄉(xiāng)醫(yī)學院基礎醫(yī)學院;徐州醫(yī)科大學護理學院;徐州醫(yī)科大學附屬醫(yī)院兒科;
【基金】：江蘇高校哲學社會科學研究一般項目(2015SJB414)
【分類號】：R722.1

【參考文獻】

相關期刊論文 前10條

1 陳曉媛;王安輝;蘇海礫;;1009例嬰幼兒先天性心臟病危險因素的病例對照研究[J];中華疾病控制雜志;2016年11期

2 江海湛;;孕期非遺傳因素作用對先天性心臟病影響的病例對照研究[J];中國現(xiàn)代藥物應用;2016年19期

3 宋龍秀;陳滇;陳進勉;蔡文雙;;湛江地區(qū)先天性心臟病高危因素調查[J];中國婦幼保健;2016年16期

4 謝燕華;孫露;;產前超聲篩查胎兒先天性心臟病的臨床意義及高危因素分析[J];中國現(xiàn)代醫(yī)生;2016年16期

5 李靜;李蓮芳;汪水成;劉華;;北京市懷柔區(qū)新生兒先天性心臟病的發(fā)病情況及母孕期高危因素分析[J];中國婦幼保健;2016年07期

6 馬玲波;;先天性心臟病與患兒父母孕前半年及孕期環(huán)境因素暴露的相關性研究[J];中國婦幼保健;2016年03期

7 李順輝;劉麗，

本文編號：2364877