不同年齡組兒童噬血細(xì)胞綜合征的臨床特點(diǎn)及預(yù)后研究
發(fā)布時(shí)間：2018-11-21 14:17
【摘要】：目的探討不同年齡組兒童噬血細(xì)胞綜合征(HPS)的臨床特點(diǎn)與預(yù)后因素分析。方法將85例HPS患兒按年齡分為0~2歲(A組)、2~8歲(B組)和8~14歲(C組),從病因、病理、臨床癥狀、實(shí)驗(yàn)室檢查及預(yù)后等方面進(jìn)行回顧性分析。結(jié)果 A、B和C組病因均以EB病毒感染為主,感染陽(yáng)性率C組明顯高于A、B組;骨髓檢查粒細(xì)胞紅細(xì)胞比例(粒紅比)小于1.0的發(fā)生率,A組高于C組;頸部淋巴結(jié)腫大發(fā)生在B組中多見(jiàn),肝脾腫大在C組中最少見(jiàn);漿膜腔積液發(fā)生在B組多見(jiàn);實(shí)驗(yàn)室檢查乳酸脫氫酶(LDH)B組高于A組,以上差異均有統(tǒng)計(jì)學(xué)意義(P0.05)。其他臨床癥狀和實(shí)驗(yàn)室檢查結(jié)果在組之間差異無(wú)統(tǒng)計(jì)學(xué)意義(P0.05)。存活與死亡患兒比較,漿膜腔積液、三酰甘油(TG)、CD4/CD8及骨髓檢查粒紅比比較,差異有統(tǒng)計(jì)學(xué)意義(P0.05),將上述因素進(jìn)行Logistic分析,顯示TG3.5mmol/L、CD4/CD81.24、骨髓粒紅比小于1.02是影響兒童HPS預(yù)后的危險(xiǎn)因素(P0.05)。結(jié)論兒童HPS有部分臨床特點(diǎn)與發(fā)病年齡有關(guān),TG、CD4/CD8及骨髓粒紅比水平是影響預(yù)后的危險(xiǎn)因素。
[Abstract]:Objective to investigate the clinical features and prognostic factors of hemophagocytic syndrome (HPS) in children of different ages. Methods Eighty-five children with HPS were divided into 3 groups according to their age: group A, group B, and group C. The etiology, pathology, clinical symptoms, laboratory examination and prognosis were analyzed retrospectively. Results EB virus infection was the main etiology in group A and C, the positive rate of infection in group C was significantly higher than that in group A, and the incidence of granulocyte ratio in group A was higher than that in group C when the ratio of granulocyte to erythrocyte in bone marrow examination was less than 1.0. Cervical lymphadenopathy was more common in group B, hepatosplenomegaly was the most rare in group C, serous cavity effusion occurred in group B. Laboratory examination of lactate dehydrogenase (LDH) B group was higher than group A, the above differences were statistically significant (P0.05). There was no significant difference between the two groups in other clinical symptoms and laboratory results (P0.05). There were significant differences between survival and death, serous cavity effusion, triglyceride (TG), CD4/CD8 and granulocyte ratio in bone marrow examination (P0.05). The above factors were analyzed by Logistic to show TG3.5mmol/L,CD4/CD81.24,. Bone marrow granulocyte ratio less than 1.02 was a risk factor for the prognosis of HPS in children (P0.05). Conclusion some clinical features of HPS in children are related to age of onset. TG,CD4/CD8 and bone marrow granulocyte ratio are risk factors for prognosis.
【作者單位】： 成都市婦女兒童中心醫(yī)院血液腫瘤科;
【分類號(hào)】：R725.5
，
本文編號(hào)：2347218
[Abstract]:Objective to investigate the clinical features and prognostic factors of hemophagocytic syndrome (HPS) in children of different ages. Methods Eighty-five children with HPS were divided into 3 groups according to their age: group A, group B, and group C. The etiology, pathology, clinical symptoms, laboratory examination and prognosis were analyzed retrospectively. Results EB virus infection was the main etiology in group A and C, the positive rate of infection in group C was significantly higher than that in group A, and the incidence of granulocyte ratio in group A was higher than that in group C when the ratio of granulocyte to erythrocyte in bone marrow examination was less than 1.0. Cervical lymphadenopathy was more common in group B, hepatosplenomegaly was the most rare in group C, serous cavity effusion occurred in group B. Laboratory examination of lactate dehydrogenase (LDH) B group was higher than group A, the above differences were statistically significant (P0.05). There was no significant difference between the two groups in other clinical symptoms and laboratory results (P0.05). There were significant differences between survival and death, serous cavity effusion, triglyceride (TG), CD4/CD8 and granulocyte ratio in bone marrow examination (P0.05). The above factors were analyzed by Logistic to show TG3.5mmol/L,CD4/CD81.24,. Bone marrow granulocyte ratio less than 1.02 was a risk factor for the prognosis of HPS in children (P0.05). Conclusion some clinical features of HPS in children are related to age of onset. TG,CD4/CD8 and bone marrow granulocyte ratio are risk factors for prognosis.
【作者單位】： 成都市婦女兒童中心醫(yī)院血液腫瘤科;
【分類號(hào)】：R725.5
，
本文編號(hào)：2347218
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