【摘要】：目的探討非免疫性胎兒水腫(NIHF)的臨床特點、診斷及治療。方法回顧分析2011年1月—2016年12月新生兒重癥監(jiān)護病房中10例診斷NIHF新生兒的臨床資料,并復(fù)習(xí)相關(guān)文獻。結(jié)果 10例NIHF中,男6例、女4例,出生胎齡32~42周,出生體質(zhì)量2.25~3.95 kg。其中感染性疾病3例(巨細胞病毒、無乳鏈球菌、微小病毒感染各1例),胎兒心血管異常2例,染色體異常2例,胸腔結(jié)構(gòu)異常1例,雙胎輸血綜合征1例,病因不明1例;臨床表現(xiàn)為2處及以上水腫(或積液)8例,僅皮膚水腫2例。最終治愈出院6例,自動出院2例,死亡2例。結(jié)論產(chǎn)前超聲是診斷NIHF的可靠方法。孕早期胎兒水腫,尤其伴有先天畸形建議終止妊娠。出生后的NIHF應(yīng)及時診治,以避免或減少嚴重并發(fā)癥。
[Abstract]:Objective to investigate the clinical features, diagnosis and treatment of non-immune fetal edema (NIHF). Methods the clinical data of 10 neonates diagnosed with NIHF in neonatal intensive care unit from January 2011 to December 2016 were retrospectively analyzed and the related literatures were reviewed. Results among the 10 cases of NIHF, 6 cases were male and 4 cases female. The gestational age was 32 ~ 42 weeks, and the birth weight was 2.25 ~ 3.95 kg.. There were 3 cases of infectious diseases (1 case of cytomegalovirus, 1 case of streptococcus lactococcus and 1 case of parvovirus infection), 2 cases of fetal cardiovascular abnormalities, 2 cases of chromosomal abnormalities, 1 case of abnormal thoracic structure, 1 case of twin transfusion syndrome and 1 case of unknown etiology. The clinical manifestations were 2 or more edema (or effusion) in 8 cases, and only 2 cases of skin edema. Finally, 6 cases were cured, 2 cases were discharged automatically and 2 cases died. Conclusion Prenatal ultrasound is a reliable method for the diagnosis of NIHF. Fetal edema in early pregnancy, especially with congenital malformations, is recommended for termination of pregnancy. Postnatal NIHF should be treated in time to avoid or reduce severe complications.
【作者單位】： 上海市兒童醫(yī)院上海交通大學(xué)附屬兒童醫(yī)院新生兒科;
【分類號】：R722.1

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