【摘要】：目的:探討新生兒先天性癥狀性巨細(xì)胞病毒(Cytomegalovirus,CMV)感染與母源性原發(fā)及復(fù)發(fā)CMV感染的相關(guān)性。方法:選取48例先天性癥狀性CMV感染新生兒及其母親為感染組,30例未感染CMV新生兒及其母親為陰性組,應(yīng)用化學(xué)發(fā)光法(CLIA)檢測(cè)兩組病例外周血特異性抗體IgM/IgG(CMV-IgM/IgG)及CMV-IgG親合力水平,熒光定量PCR法檢測(cè)兩組母親乳汁、新生兒外周血及尿液中CMV-DNA含量,分析比較其檢測(cè)結(jié)果的差異并回顧性分析比較了兩組母親孕早期CMV-IgG的濃度水平與本次結(jié)果的差異。結(jié)果:感染組母親外周血CMV-IgG抗體水平及乳汁CMV-DNA陽性率顯著高于對(duì)照組,差異有統(tǒng)計(jì)學(xué)意義(P均0.01);病例組患兒與母親CMV特異性IgG抗體比值小于對(duì)照組,差異有統(tǒng)計(jì)學(xué)意義(P均0.01);感染組子母間IgG測(cè)定值為負(fù)相關(guān)性,差異有統(tǒng)計(jì)學(xué)意義(P0.01);陰性組子母間IgG測(cè)定值為正相關(guān)性,差異有統(tǒng)計(jì)學(xué)意義(P0.01);感染組母親孕早期CMV-IgG濃度水平顯著低于本次結(jié)果,差異有統(tǒng)計(jì)學(xué)意義(P0.01);陰性組母親孕早期CMV-IgG濃度水平與本次結(jié)果無顯著性差異(P0.05)。結(jié)論:孕婦體內(nèi)CMV活化或再感染導(dǎo)致CMV-IgG水平升高,是新生兒先天性癥狀性CMV感染的高危因素,孕期應(yīng)關(guān)注CMV-IgM/IgG動(dòng)態(tài)監(jiān)測(cè)。
[Abstract]:Objective: to investigate the relationship between congenital symptomatic cytomegalovirus (Cytomegalovirus,CMV) infection and maternal primary and recurrent CMV infection. Methods: 48 neonates and their mothers with congenital symptomatic CMV infection were selected as infection group, and 30 uninfected CMV newborns and their mothers were selected as negative group. The levels of specific antibody IgM/IgG (CMV-IgM/IgG) and CMV-IgG in peripheral blood of two groups were detected by chemiluminescence assay (CLIA), and the content of CMV-DNA in mother's milk, newborn blood and urine were detected by fluorescence quantitative PCR method. The differences of CMV-IgG levels in the first trimester of pregnancy between the two groups were analyzed and compared retrospectively. Results: the levels of CMV-IgG antibody in peripheral blood and the positive rate of CMV-DNA in milk of infected mothers were significantly higher than those in control group (P0.01). The ratio of CMV specific IgG antibody to mother in the case group was significantly lower than that in the control group (P0.01), and the IgG level in the infected group was negatively correlated with that of the mother (P0.01). There was a positive correlation between mothers and mothers in negative group, the difference was statistically significant (P0.01), and the level of CMV-IgG in infected mothers was significantly lower than that in the first trimester of pregnancy (P0.01). There was no significant difference in the level of CMV-IgG between the mothers in the negative group and this result (P 0.05). Conclusion: the activation or reinfection of CMV in pregnant women leads to the increase of CMV-IgG level, which is a high risk factor for congenital symptomatic CMV infection in neonates. The dynamic monitoring of CMV-IgM/IgG should be paid attention to during pregnancy.
【作者單位】： 寧夏醫(yī)科大學(xué)總醫(yī)院醫(yī)學(xué)實(shí)驗(yàn)中心;
【基金】：寧夏自然科學(xué)基金項(xiàng)目(NZ14148)
【分類號(hào)】：R722.13

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