中藥分期論治小兒咳嗽變異性哮喘（虛寒證）的臨床研究
發(fā)布時間：2018-10-24 15:40
【摘要】：[目的]觀察中藥分期論治CVA的臨床療效,為中醫(yī)藥治療CVA提供有效的方劑,為新藥開發(fā)提供臨床依據(jù)。 [方法]將60例CVA患兒隨機分為治療組和對照組,每組30例,治療組采用中藥分期論治(發(fā)作期使用溫肺化痰飲,緩解期使用補肺健脾飲)治療,療程3月；對照組西藥治療(予孟魯司特鈉治療3個月,發(fā)作期加用氨荼堿)。分別在治療前、治療2周、1月、2月和療程結束(治療3月后)時對疾病療效和中醫(yī)證候積分進行評估。 [結果]1.疾病療效治療組總有效率93.33%,對照組總有效率93.33%,兩組差異無統(tǒng)計學意義(P＞0.05),兩組疾病療效相當。2.中醫(yī)證候療效治療組總有效率96.67%,對照組總有效率90.00%,兩組差異有顯著統(tǒng)計學意義(P＜0.01),治療組明顯優(yōu)于對照組。3.治療組咳嗽平均消失時間6.13±1.87天,對照組咳嗽平均消失時間3.87±1.22天,差異有統(tǒng)計學意義(P＜0.05),對照組優(yōu)于治療組。4.治療前后主證咳嗽積分比較：兩組主證咳嗽積分與治療后比較有顯著統(tǒng)計學意義(P＜0.01),兩組治療后積分明顯優(yōu)于治療前。兩組治療后比較無統(tǒng)計學意義(P＞0.05),兩組治療療效相當。5.治療前后次要癥狀的比較：兩組次要癥狀積分與治療前比較有統(tǒng)計學意義(P＜0.05),兩組對次要癥狀均有改善作用。治療后兩組比較,在“自汗、神疲乏力、食少納呆、大便異常、面白形寒”這5個方面有顯著統(tǒng)計學意義(P＜0.01),治療組癥狀改善明顯優(yōu)于對照組；在“揉眼、揉鼻噴嚏”這2項差異無統(tǒng)計學意義(P＞0.05),兩組癥狀改善情況相當。6.兩組治療后各時間點與前一時間點比較：差異有統(tǒng)計學意義(P0.05),兩組均能改善此病中醫(yī)癥狀。7.中醫(yī)總證候積分比較：兩組治療前后比較有顯著統(tǒng)計學意義(P0.01),兩組均能改善此病中醫(yī)癥狀；治療后兩組中比較有顯著統(tǒng)計學意義(P0.01),治療組療效明顯優(yōu)于對照組。 [結論]中藥分期論治CVA主證咳嗽與西藥組療效相當,在治療次要癥狀改善上效果明顯優(yōu)于西藥組。
[Abstract]:Objective: to observe the clinical effect of CVA by stages of Chinese medicine, to provide effective prescription for CVA and to provide clinical basis for the development of new drugs. [methods] 60 children with CVA were randomly divided into treatment group (n = 30) and control group (n = 30). The treatment group was treated with traditional Chinese medicine by stages (Wenfei Huatan decoction in attack period, Bufei Jianpi decoction in remission period) for 3 months. The control group was treated with western medicine (montelukast sodium for 3 months, paroxysm plus ambromine). Before treatment, 2 weeks, 1 month, 2 months and the end of the course of treatment (after 3 months of treatment), the curative effect of the disease and the score of TCM syndromes were evaluated respectively. [result] 1. The total effective rate of the disease treatment group was 93.33 and that of the control group was 93.33. There was no significant difference between the two groups (P > 0.05). The total effective rate of TCM syndrome treatment group was 96.67 and that of control group was 90.00.The difference between the two groups was statistically significant (P < 0.01). The treatment group was significantly better than the control group (P < 0.01). The average time of cough disappearance was 6.13 鹵1.87 days in the treatment group and 3.87 鹵1.22 days in the control group (P < 0.05). Comparison of cough score before and after treatment: there was significant difference between the two groups before and after treatment (P < 0.01), and the score after treatment in two groups was significantly better than that before treatment. There was no significant difference between the two groups after treatment (P > 0.05). Comparison of secondary symptoms before and after treatment: the scores of secondary symptoms in the two groups were significantly higher than those before treatment (P < 0.05). After treatment, there were significant differences between the two groups in the five aspects of "self-sweating, fatigue, less food intake, abnormal stool, and cold face" (P < 0.01). The improvement of symptoms in the treatment group was significantly better than that in the control group (P < 0.01), and the improvement of symptoms in the treatment group was significantly better than that in the control group (P < 0.01). There was no significant difference between the two groups (P > 0.05), and the improvement of symptoms in the two groups was similar to that in the control group (6. 6%, P > 0. 05). Two groups after treatment at each time point compared with the previous time point: the difference was statistically significant (P0.05), the two groups can improve the symptoms of traditional Chinese medicine. Comparison of the total syndromes of TCM: there was significant difference between the two groups before and after treatment (P0.01), both groups could improve the TCM symptoms of the disease; after treatment, the two groups had significant statistical significance (P0.01), the curative effect of the treatment group was significantly better than that of the control group. [conclusion] the effect of traditional Chinese medicine in treating CVA cough by stages is similar to that in western medicine group, and it is better than that in western medicine group in the treatment of secondary symptoms.
【學位授予單位】：湖南中醫(yī)藥大學
【學位級別】：碩士
【學位授予年份】：2012
【分類號】：R272
本文編號：2291795
[Abstract]:Objective: to observe the clinical effect of CVA by stages of Chinese medicine, to provide effective prescription for CVA and to provide clinical basis for the development of new drugs. [methods] 60 children with CVA were randomly divided into treatment group (n = 30) and control group (n = 30). The treatment group was treated with traditional Chinese medicine by stages (Wenfei Huatan decoction in attack period, Bufei Jianpi decoction in remission period) for 3 months. The control group was treated with western medicine (montelukast sodium for 3 months, paroxysm plus ambromine). Before treatment, 2 weeks, 1 month, 2 months and the end of the course of treatment (after 3 months of treatment), the curative effect of the disease and the score of TCM syndromes were evaluated respectively. [result] 1. The total effective rate of the disease treatment group was 93.33 and that of the control group was 93.33. There was no significant difference between the two groups (P > 0.05). The total effective rate of TCM syndrome treatment group was 96.67 and that of control group was 90.00.The difference between the two groups was statistically significant (P < 0.01). The treatment group was significantly better than the control group (P < 0.01). The average time of cough disappearance was 6.13 鹵1.87 days in the treatment group and 3.87 鹵1.22 days in the control group (P < 0.05). Comparison of cough score before and after treatment: there was significant difference between the two groups before and after treatment (P < 0.01), and the score after treatment in two groups was significantly better than that before treatment. There was no significant difference between the two groups after treatment (P > 0.05). Comparison of secondary symptoms before and after treatment: the scores of secondary symptoms in the two groups were significantly higher than those before treatment (P < 0.05). After treatment, there were significant differences between the two groups in the five aspects of "self-sweating, fatigue, less food intake, abnormal stool, and cold face" (P < 0.01). The improvement of symptoms in the treatment group was significantly better than that in the control group (P < 0.01), and the improvement of symptoms in the treatment group was significantly better than that in the control group (P < 0.01). There was no significant difference between the two groups (P > 0.05), and the improvement of symptoms in the two groups was similar to that in the control group (6. 6%, P > 0. 05). Two groups after treatment at each time point compared with the previous time point: the difference was statistically significant (P0.05), the two groups can improve the symptoms of traditional Chinese medicine. Comparison of the total syndromes of TCM: there was significant difference between the two groups before and after treatment (P0.01), both groups could improve the TCM symptoms of the disease; after treatment, the two groups had significant statistical significance (P0.01), the curative effect of the treatment group was significantly better than that of the control group. [conclusion] the effect of traditional Chinese medicine in treating CVA cough by stages is similar to that in western medicine group, and it is better than that in western medicine group in the treatment of secondary symptoms.
【學位授予單位】：湖南中醫(yī)藥大學
【學位級別】：碩士
【學位授予年份】：2012
【分類號】：R272
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