【摘要】：目的 探討兒童幽門螺桿菌(Hp)感染與全血微量元素、血清瘦素水平的關(guān)系,為臨床治療提供參考及進一步明確臨床意義。 方法 2011年5月-10月在中南大學(xué)湘雅二醫(yī)院兒科門診就診的1-14歲兒童,選取具有上消化道癥狀(包括上腹痛或臍周痛、嘔吐、食欲不振等)的兒童101例。其中男54例,女47例。通過酶聯(lián)免疫吸附分析(ELISA)法測定Hp抗體,其中陽性者56例,陰性者45例。Hp陽性者中男29例,女27例,陰性者中男25例,女20例。通過火焰原子吸收法測定兩組兒童全血微量元素(銅、鋅、鈣、鎂、鐵)的含量。通過ELISA法測定兩組兒童血清瘦素水平。應(yīng)用SPSS17.0統(tǒng)計軟件分析兩組兒童血微量元素、瘦素水平的變化。 結(jié)果 1.Hp感染與年齡有關(guān)(P0.05)；2.Hp陽性組和Hp陰性組兒童性別比較無顯著性差異(P0.05)；3.Hp陽性組和Hp陰性組兒童全血鈣、鎂、銅含量比較無顯著差異性(P0.05),Hp陽性組鋅、鐵含量低于Hp陰性組,且差別具有統(tǒng)計學(xué)意義(P0.05)；4.Hp陽性組血清瘦素水平低于Hp陰性組,但差異無統(tǒng)計學(xué)意義(P0.05)；5.男性血清瘦素水平低于女性,差異無統(tǒng)計學(xué)意義(P0.05)。男性及女性兒童Hp陽性組與Hp陰性組血清瘦素水平間差異無統(tǒng)計學(xué)意義(P0.05)。 結(jié)論 1.兒童幽門螺桿菌感染率隨著年齡的增長而增加,與性別無明顯相關(guān)性；2.幽門螺桿菌感染與兒童鋅、鐵缺乏相關(guān),對幽門螺桿菌感染患兒應(yīng)進行鋅、鐵元素測定,及時給予治療,糾正鋅、鐵的不足,以減少由此引起的鋅、鐵缺乏對兒童生長發(fā)育的影響；3.幽門螺桿菌感染對血清瘦素水平?jīng)]有影響；性別對血清瘦素水平?jīng)]有影響。
[Abstract]:Objective to investigate the relationship between Helicobacter pylori (Hp) infection and serum leptin and trace elements in children, and to provide reference for clinical treatment and further clarify clinical significance. Methods from May to October 2011, 101 children with upper gastrointestinal symptoms (including upper abdominal pain or periumbilical pain, vomiting, loss of appetite, etc.) were selected from a pediatric outpatient clinic of Xiangya second Hospital of Central South University. There were 54 males and 47 females. (ELISA) assay was used to detect Hp antibody in 56 cases of positive and 45 cases of negative Hp. 29 cases were male, 27 cases were female, 25 cases were male and 20 cases were female. The contents of trace elements (Cu, Zn, Ca, mg, Fe) in whole blood of children in two groups were determined by flame atomic absorption spectrometry. Serum leptin levels were measured by ELISA method. The changes of serum trace elements and leptin levels in two groups were analyzed by SPSS17.0 software. Results 1.Hp infection was associated with age (P0.05), there was no significant difference in sex between 2.Hp positive group and Hp negative group (P0.05), and there was no significant difference in total blood calcium, magnesium and copper content between 3.Hp positive group and Hp negative group (P0.05). Iron content was lower than that of Hp negative group, and the difference was statistically significant (P0.05); the serum leptin level in 4.Hp positive group was lower than that in Hp negative group, but the difference was not statistically significant (P0.05). The serum leptin level of male was lower than that of female, the difference was not statistically significant (P0.05). There was no significant difference in serum leptin levels between male and female Hp positive group and Hp negative group (P0.05). Conclusion 1. The infection rate of Helicobacter pylori in children increased with age, and had no significant correlation with sex. 2. Helicobacter pylori infection is associated with zinc and iron deficiency in children. Children with Helicobacter pylori infection should be tested for zinc and iron, treated in time to correct the deficiency of zinc and iron in order to reduce the resulting zinc. The effect of iron deficiency on the growth and development of children. Helicobacter pylori infection had no effect on serum leptin level, while gender had no effect on serum leptin level.
【學(xué)位授予單位】：中南大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2012
【分類號】：R725.7

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