【摘要】：目的：提高年輕醫(yī)師對噬血細(xì)胞綜合征的認(rèn)識及積累診治經(jīng)驗(yàn)。 方法：報(bào)告一例兒童噬血細(xì)胞綜合征的臨床表現(xiàn)、實(shí)驗(yàn)室檢查、診治經(jīng)過及文獻(xiàn)復(fù)習(xí)。 設(shè)計(jì)：病例報(bào)告。 病例：一例8歲男性患兒,病程中主要表現(xiàn)為發(fā)熱、全身瘀斑、肝脾腫大、全血細(xì)胞減少,肝功能嚴(yán)重?fù)p害,綜合患兒實(shí)驗(yàn)室檢查符合噬血細(xì)胞綜合征診斷標(biāo)準(zhǔn)。干預(yù)：開始時(shí)經(jīng)積極抗感染、血漿及紅細(xì)胞、靜脈用丙種球蛋白、糖皮質(zhì)激素及對癥等治療,病情好轉(zhuǎn)。但上呼吸道感染后,臨床癥狀、體征再次加重,在上述治療基礎(chǔ)上加用依托泊苷化療后病情得到很快控制,癥狀、體征明顯改善,實(shí)驗(yàn)室各項(xiàng)指標(biāo)基本恢復(fù)正常。但經(jīng)再次感染后,臨床癥狀較前次加重,繼續(xù)原方案治療。 結(jié)果：治療效果欠佳,家長放棄繼續(xù)在我院治療,自動出院。 結(jié)論：噬血細(xì)胞綜合征是一類少見的惡性血液性疾病,病情進(jìn)展快,死亡率高,早期控制基礎(chǔ)疾病的同時(shí),積極免疫—化療的治療是較為恰當(dāng)?shù)闹委煛?br/>[Abstract]:Objective: to improve the knowledge of young doctors on hemophagocytic syndrome and accumulate experience in diagnosis and treatment. Methods: a case of hemophagocytic syndrome in children was reported. Design: case report. Case: an 8-year-old male patient with fever, systemic ecchymosis, hepatosplenomegaly, decreased whole blood cells and severe damage of liver function was found in the course of the disease. The laboratory examination of the patient was in accordance with the diagnostic criteria of hemophagocytic syndrome. Interventions: after active anti-infection, plasma and red blood cell, intravenous gamma globulin, glucocorticoid and symptomatic treatment, etc. But after the upper respiratory tract infection, the clinical symptoms and signs became more serious again. The symptoms and signs were obviously improved and the laboratory indexes were basically restored to normal after the treatment with etoposide chemotherapy. But after re-infection, the clinical symptoms were more severe than the previous, continue the original treatment. Results: the effect of treatment was poor, parents gave up to continue treatment in our hospital, automatic discharge. Conclusion: hemophagocytic syndrome is a rare malignant hematologic disease with rapid progression and high mortality.
【學(xué)位授予單位】：蘭州大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2012
【分類號】：R725.5

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