【摘要】：目的通過免疫熒光抗原檢測技術動態(tài)監(jiān)測流感患兒流感病毒抗原,觀察患兒抗原轉陰時間和臨床癥狀消失時間,以及兩者之間的關系。方法對2016年3~4月就診于湖南省人民醫(yī)院的1 063例疑似流感患兒運用甲乙型流感病毒抗原檢測試劑盒(免疫熒光法)行流感病毒抗原檢測,陽性者予以奧司他韋抗病毒治療;并囑咐患者起病后5 d內、5~7 d及7 d后3個時間段復查流感病毒抗原。結果 1 063例疑似流感病例中,流感病毒檢出560例(52.68%)。對215例流感病毒陽性患兒進行隨訪,起病5 d內流感病毒抗原轉陰率為9.8%(21例),5~7 d內累積轉陰率為32.1%(69例),7~10 d累積轉陰率為98.1%(211例);起病3 d內臨床癥狀改善率為2.8%(6例),3~5 d臨床癥狀改善累積率為84.7%(182例),5 d后所有患兒臨床癥狀均得到改善。結論流感患兒經治療臨床癥狀改善時間早于抗原消失時間;起病7~10 d后流感病毒抗原近100%轉陰,推測患兒在起病7~10 d、臨床癥狀消失后返校是相對安全的。
[Abstract]:Objective to dynamically monitor influenza virus antigen in children with influenza by immunofluorescence antigen detection technique, and to observe the time of negative change of antigen and the time of disappearance of clinical symptoms, and the relationship between them. Methods from March to April 2016, 1 063 cases of suspected influenza in Hunan Provincial people's Hospital were tested with influenza A and B virus antigen test kit (immunofluorescence method), and those who were positive were treated with oseltamivir antiviral therapy. The patients were ordered to check the influenza virus antigen within 5 days after the onset of the disease and within 5 days and 7 days after the onset of influenza virus antigen. Results among 1 063 suspected influenza cases, 560 cases (52.68%) were detected by influenza virus. 215 cases of influenza virus positive children were followed up. The negative conversion rate of influenza virus antigen within 5 days was 9.8% (21 cases). The cumulative negative conversion rate was 32.1% (69 cases) within 7 days, 98.1% (211 cases) in 10 days, and 2.8% (6 cases) in 3 days. The cumulative rate of clinical symptom improvement was 84.7% (182 cases) in 35 days. The clinical symptoms of all the children were improved. Conclusion the improvement time of clinical symptoms of children with influenza is earlier than the time of disappearance of antigens, and it is safe to return to school after 710 days of onset and 100% of influenza virus antigens turn negative.
【作者單位】： 湖南省人民醫(yī)院兒童醫(yī)學中心/湖南省師范大學第一附屬醫(yī)院;
【分類號】：R725.1

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